57371-44-5

Basic information

• Product Name: 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol
• Synonyms: 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol
• CAS NO: 57371-44-5
• Molecular Formula: C₁₇H₂₀O₃
• Molecular Weight: 272.3389
• Mol File: 57371-44-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol(57371-44-5)
• EPA Substance Registry System: 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol(57371-44-5)

Safety Data

• Hazardous Substances Data: 57371-44-5(Hazardous Substances Data)

Usage

General Description

3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol, also known as 3-(4-(Benzyloxy)-3-Methoxyphenyl)propanol, is a chemical compound with the molecular formula C17H20O3. It is a colorless liquid that is commonly used in organic synthesis and pharmaceutical research. 3-(4-(Benzyloxy)-3-Methoxyphenyl)propan-1-ol contains a benzyl ether group, a methoxy group, and a hydroxyl group, making it a versatile building block for the synthesis of various organic compounds. It is often used as an intermediate in the production of pharmaceuticals and agrochemicals, and its unique structure provides opportunities for the development of new drugs and materials. Additionally, this compound has potential applications in the field of organic chemistry and is widely used in academic and industrial research laboratories.

Upstream product

• 186895-24-9 ethyl 3-(4-(benzyloxy)-3-methoxy)propanoate 
• 93878-20-7 methyl (E)-3-[4-(benzyloxy)-3-methoxyphenyl]acrylate 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 38157-08-3 (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester 
• 28028-62-8 ethyl ferulate 
• 100-39-0 benzyl bromide 
• 121-33-5 vanillin 
• 57371-42-3 4-allyl-1-benzyloxy-2-methoxybenzene 
• 97-53-0 4-allylguaiacol 
• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 
• 2309-07-1 Methyl ferulate 
• 1700-32-9 methyl 4-benzyloxy-3-methoxybenzenepropanoate 
• 1391731-13-7 3-[4-(benzyloxy)-3-methoxyphenyl]prop-2-yn-1-ol 

Downstream Products

• 69172-20-9 3-(3-methoxy-4-benzyloxyphenyl)propionaldehyde 
• 185254-99-3 Diazo-acetic acid 3-(4-benzyloxy-3-methoxy-phenyl)-propyl ester 
• 111266-03-6 (R)-(+)-3-(4-benzyloxy-3-methoxybenzyl)-γ-butyrolactone 
• 124988-58-5 (S)-4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone 
• 23513-08-8 [8]-gingerol 
• 23513-15-7 10-gingerol 
• 39886-76-5 [6]-gingerol 
• 146830-53-7 2-<2-(4-Hydroxy-3-methoxyphenyl)ethyl>-1,3-dithiane 
• 146830-57-1 (+)(6S)-10-(4-Hydroxy-3-methoxyhenyl)-8,8-(1,3-propanediyldithio)-6-hydroxy-1-<(tert-butyldiphenylsilyl)oxy>decane 
• 127766-48-7 1-Benzyloxy-2-methoxy-4-(3-nitro-propyl)-benzene 

Relevant articles and documents

First Enantioselective Synthesis of Surinamensinol B and a Non-Natural Polysphorin Analogue by a Two-Stereocentered Hydrolytic Kinetic Resolution

An efficient and economical approach to the synthesis of antitumor and anti-inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96 % ee) by starting from commercially available 3,4,5-trimethoxybenzaldehyde. The key steps of the strategy include a Co-catalyzed two-stereocentered hydrolytic kinetic resolution (HKR) of racemic 2-[(methoxymethoxy)(3,4,5-trimethoxyphenyl)methyl]oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.

The first stereoselective total synthesis of a new antitumour and anti-inflammatory neolignan, surinamensinol A

The stereoselective total synthesis of an antitumour and anti-inflammatory 8-O-4′-neolignan, surinamensinol A has been accomplished starting from two aldehydes, 3,4,5-trimethoxy benzaldehyde and vanillin. The key steps involve an asymmetric reduction using a chiral oxazaborolidine complex, a Sharpless asymmetric dihydroxyllation and a Mitsunobu reaction. This is the first report of the total synthesis of surinamensinol A.

Synthesis of gingerol and diarylheptanoids

The synthesis of gingerol 1 and related compounds 2-5 along with diarylheptanoids 6-8 has been accomplished using a Keck allylation, Crimmins' aldol reaction, aldehyde coupling with acetylene, and chelation controlled reductions as the key reactions. The absolute configuration of these molecules was confirmed by preparing their acetonide derivatives and by comparison of the NMR data with natural compounds.