1360189-08-7

Basic information

• Product Name: ethyl 2-acetamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
• CAS NO: 1360189-08-7
• Molecular Weight: 383.444
• Mol File: 1360189-08-7.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-acetamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-acetamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(1360189-08-7)
• EPA Substance Registry System: ethyl 2-acetamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(1360189-08-7)

Safety Data

• Hazardous Substances Data: 1360189-08-7(Hazardous Substances Data)

Upstream product

• 126-81-8 dimedone 
• 105-56-6 ethyl 2-cyanoacetate 
• 107752-93-2 ethyl 2-amino-4-phenyl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran-3-carboxylate 
• 75-36-5 acetyl chloride 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Synthesis of 2-amide-3-carboxylate-4-aryl-4H-chromene derivatives

Tetrabutyl ammonium bromide (TBAB) catalyzed one-pot synthesis of 4H-chromene via a three-component cyclocondensation of aryl aldehydes, cyanoacetate and dimedone in green media-water. Then, 4H-chromene reacted with acyl chloride in acetonitrile at refluxing with catalytic amount of DMAP to yield the title compounds in good yields. The structures of all title compounds were confirmed by 1H NMR, MS and elementary analyses. The X-ray crystallography of compound 3n indicated that there were strong intermolecular hydrogen bonds. Springer Science+Business Media B.V. 2012.