136029-15-7

Upstream product

• 3292-77-1 2-bromo-1-thiazol-2-yl-ethanone 
• 603-35-0 triphenylphosphine 
• 136029-16-8 ((2-thiazolylcarbonyl)methyl)triphenylphosphonium bromide 

Downstream Products

• 154796-74-4 (4R,5R,6S,7R)-4-O-benzyl-4,5,6,7,8-pentahydroxy-5,6:7,8-di-O-isopropylidene-1-(2-thiazolyl)-2(E)-octen-1-one 
• 154796-68-6 (4R,5R,6S,7S)-8-(O-tert-butyldiphenylsilyl)-4,5,6,7,8-pentahydroxy-4,6:5,7-di-O-isopropylidene-1-(2-thiazolyl)-2(E)-octen-1-one 
• 612830-71-4 5,9-anhydro-6,7,8,10-tetra-O-benzyl-2,3,4-trideoxy-1-C-(2-thiazolyl)-D-glycero-D-ido-dec-2-enose 
• 197085-15-7 NbCl₃(C₃H₂NSC(CHP(C₆H₅)3)O)(CH₃CCCH₃) 
• 197085-11-3 [NbCl₃(C₃H₂NSC(CHP(C₆H₅)3)O)]2 
• 197085-13-5 NbCl₃(C₃H₂NSC(CHP(C₆H₅)3)O)(C₆H₅CCC₆H₅) 
• 197085-19-1 NbCl₃(C₃H₂NSC(CHP(C₆H₅)3)O)(C₆H₅CCCH₃) 
• 1314380-02-3 (E)-4-(2,3,4,6-tetra-O-benzyl-β-D-mannopyranosyl)-1-(thiazol-2-yl)-but-2-en-1-one 
• 1314380-01-2 (E)-4-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-1-(thiazol-2-yl)-but-2-en-1-one 
• 1314380-10-3 (2R,4R)-2-[(S)-2-(benzyloxy)-1-phenylethoxy]-4-[(2,3,4,6-tetra-O-benzyl-β-D-mannopyranosyl)methyl]-6-(thiazol-2-yl)-3,4-dihydro-2H-pyran 
• 1314380-11-4 (2S,4S)-2-[(R)-2-(benzyloxy)-1-phenylethoxy]-4-[(2,3,4,6-tetra-O-benzyl-β-D-mannopyranosyl)methyl]-6-(thiazol-2-yl)-3,4-dihydro-2H-pyran 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH

A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS

A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

Installation of the pyruvate unit in glycidic aldehydes via a Wittig olefination-Michael addition sequence utilizing a thiazole-armed carbonyl ylid. A new stereoselective route to 3-deoxy-2-ulosonic acids and the total synthesis of DAH, KDN, and 4-epi-KDN

A method for the installation of the (2-thiazolylcarbonyl)methylene group, i.e. a masked pyruvate unit owing to the thiazole to formyl equivalence, in sugar-derived aldehydes has been developed. The strategy involves stereoselective carbon-carbon and carb

Stereoselective construction of polyhydroxyalkyl 2-thiazolyl ketones (thiazole ketones) from D-glyceraldehyde and D-arabinose acetonides by Wittig-Michael sequence. A route to D-gluco-KDO

The carbonylolefination of the title alkoxy aldehydes by 2-thiazolecarbonylmethylenetriphenylphosphorane affords the corresponding (E)-enones which undergo syn-diastereoselective (ds, 85-95%) 1,4-conjugate addition of benzyl oxide anion; acid-catalyzed me