136049-85-9Relevant academic research and scientific papers
Synthesis and antiviral evaluation of 3'-substituted thymidine analogues derived from 3'-amino-3'-deoxythymidine
Pannecouque,Van Poppel,Balzarini,Claes,De Clercq,Herdewijn
, p. 541 - 544 (1995)
To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-functionalized thymidine analogues were synthesized. Several of these thymidine analogues show moderate in vitro activity against HIV-1 and HIV-2.
Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine
Pannecouque, Christophe,Busson, Roger,Balzarini, Jan,Claes, Paul,De Clercq, Erik,Herdewijn, Piet
, p. 5369 - 5380 (2007/10/02)
Based on the structure-activity relationship for antiviral activity, a series of 3′-deoxy-3′-N-functionalized thymidine analogues derived from 3′-amino-3′-deoxythymidine was synthesized. These compounds were evaluated for their antiviral activity. Three of the prepared molecules namely 3′-(1,2,4-triazol-1-yl)carbimidoylamino-3′-deoxythymidine 6, 3′-(3-amino-1-methyl-1,2,4-triazol-5-yl)amino-3′-deoxythymidine 8b and 3′-N-cyano-O-phenylisourea-3′-deoxythymidine 7 show moderate but selective in vitro activity against HIV-1 and HIV-2. These data demonstrate that some steric bulk in the 3′-position is compatible with anti-HIV activity. Copyright
Synthesis, Enzymatic Stability And Physicochemical Properties Of Oligonucleotides Containing A N-Cyanoguanidine Linkage.
Pannecouque, C.,Vandendriessche, F.,Rozenski, J.,Janssen, G.,Busson, R.,et. al
, p. 7231 - 7246 (2007/10/02)
Nucleoside dimers with a N-cyanoguanidine linkage were synthesized and used as building blocks for oligonucleotide synthesis.Oligonucleotides composed of alternating phosphodiester and cyanoguanidine functions are still able to hybridize with a complementary natural oligodeoxynucleotide.
Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis
Pannecouque,Wigerinck,Van Aerschot,Herdewijn
, p. 7609 - 7612 (2007/10/02)
Synthesis of dimeric nucleoside building blocks with a N-cyanoguanidine linkage was performed by reaction of 3'-amino-3'-deoxythymidine with S,S-dimethyl-N-cyanodithioimidocarbonate followed by reaction of the obtained isothiourea with 5'-amino-2',5'-dideoxynucleosides. These dimers were protected in the 5'-position and converted into their phosphoramidites. Oligonucleotides were synthesized using these building blocks.
