Synthesis and antiviral evaluation of 3'-substituted thymidine analogues derived from 3'-amino-3'-deoxythymidine

Article abstract of DOI:10.1080/15257779508012422

To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-functionalized thymidine analogues were synthesized. Several of these thymidine analogues show moderate in vitro activity against HIV-1 and HIV-2.

Full text of DOI:10.1080/15257779508012422

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Nucleosides and Nucleotides
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Synthesis and Antiviral Evaluation
of 3′-Substituted Thymidine
Analogues Derived from 3′-Amino-3′-
deoxythymidine
C. Pannecouque a , K. Van Poppel a , J. Balzarini a , P. Claes a , E. De
Clercq a & P. Herdewijn a
a Laboratory of Medicinal Chemistry (F. F. W.) , Rega Institute
for Medical Research, Katholieke Universiteit Leuven ,
Minderbroedersstraat, 10, B-3000, Leuven, Belgium
Published online: 16 Feb 2007.
To cite this article: C. Pannecouque , K. Van Poppel , J. Balzarini , P. Claes , E. De Clercq & P.
Herdewijn (1995) Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived
from 3′-Amino-3′-deoxythymidine, Nucleosides and Nucleotides, 14:3-5, 541-544
To link to this article: http://dx.doi.org/10.1080/15257779508012422
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