146691-40-9Relevant academic research and scientific papers
Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis
Pannecouque,Wigerinck,Van Aerschot,Herdewijn
, p. 7609 - 7612 (1992)
Synthesis of dimeric nucleoside building blocks with a N-cyanoguanidine linkage was performed by reaction of 3'-amino-3'-deoxythymidine with S,S-dimethyl-N-cyanodithioimidocarbonate followed by reaction of the obtained isothiourea with 5'-amino-2',5'-dideoxynucleosides. These dimers were protected in the 5'-position and converted into their phosphoramidites. Oligonucleotides were synthesized using these building blocks.
