13605-19-1Relevant articles and documents
Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor γ/δ agonists We dedicate this article to Professor Young-Ger Suh on the occasion of his retirement.
Gim, Hyo Jin,Li, Hua,Jeong, Ji Hye,Lee, Su Jeong,Sung, Mi-Kyung,Song, Mi-Young,Park, Byung-Hyun,Oh, Soo Jin,Ryu, Jae-Ha,Jeon, Raok
supporting information, p. 3322 - 3336 (2015/08/03)
Abstract A series of alkoxy-3-indolylacetic acid analogs has been discovered as peroxisome proliferator-activated receptor (PPAR) agonists. Structure-activity relationship study indicated that PPARα/γ/δ activities were dependent on the nature of the hydrophobic group, the attachment position of the alkoxy linker to the indole ring, and N-alkylation of indole nitrogen. Some compounds presented significant PPARγ/δ activity and molecular modeling suggested their putative binding modes in the ligand binding domain of PPARγ. Of these, compound 51 was selected for in vivo study via an evaluation of microsomal stability in mouse and human liver. Compound 51 lowered the levels of fasting blood glucose, insulin, and HbA1c without gain in body weight in db/db mice. When compound 51 was treated, hepatic triglycerides level and the size of adipocytes in white adipose tissue of db/db mice were also reduced as opposed to treatment with rosiglitazone. Taken together, compound 51 shows high potential warranting further studies in models for diabetes and related metabolic disorders and may be in use as a chemical tool for the understanding of PPAR biology.
Borohydride exchange resin: Selective reduction of aliphatic carboxylic acids
Joshi, D. D.,Sagar, A. D.,Hilage, N. P.,Salunkhe, M. M.
, p. 1201 - 1202 (2007/10/02)
The aliphatic carboxylic acids can be reduced selectively to the corresponding alcohol in the presence of aromatic carboxylic acids within 30 min with borohydride exchange resin (BER).
Dye mixtures of anthraquinone dyes
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, (2008/06/13)
Dye mixtures containing at least two dyes of the formula (1) STR1 wherein R is hydrogen, methyl or ethyl, and n is an integer from 2 to 4, exhibit on synthetic textile material a build-up which is considerably better than that of the individual dyes.