1360538-87-9

Usage

Uses

Used in Pharmaceutical Applications:
(S)-N-1-[(3-hydroxypropyl)amino]propan-2-yl-2-nitrobenzenesulfonamide is used as a potential medicine for treating various cardiovascular conditions such as hypertension and heart failure. Its unique structure with a nitro group and a sulfonamide moiety contributes to its bioactivity, making it a valuable compound in the development of new therapeutic agents for cardiovascular health.
Used in Chemical Research:
In the field of chemical research, (S)-N-1-[(3-hydroxypropyl)amino]propan-2-yl-2-nitrobenzenesulfonamide can be utilized as a starting material or a building block for the synthesis of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
It is crucial to handle (S)-N-1-[(3-hydroxypropyl)amino]propan-2-yl-2-nitrobenzenesulfonamide with care and adhere to proper safety protocols when working with (S)-N-{1-[(3-hydroxypropyl)amino]propan-2-yl}-2-nitrobenzenesulfonamide in both chemical and pharmaceutical settings.

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 1411975-57-9 (R)-N-(2-hydroxy-1-methylethyl)-2-nitrobenzenesulfonamide 
• 156-87-6 propan-1-ol-3-amine 

Downstream Products

• 1360538-88-0 (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]-1,4-diazepane hydrochloride 
• 1360538-89-1 (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]-1,4-diazepane 
• 949109-36-8 tert-butyl (S)-3-methyl-4-[(2-nitrophenyl)sulfonyl]-1,4-diazepane-1-carboxylate 
• 194032-32-1 tert-butyl (S)-3-methyl-1,4-diazepane-1-carboxylate 
• 223645-67-8 ripasudil 

Relevant academic research and scientific papers

Synthesis of oxidative metabolites of K-115, a novel Rho-kinase inhibitor

In humans, oxidative metabolites 2–4 of (S)-4-fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)-isoquinoline hydrochloride dihydrate (K-115, 1), a novel Rho-kinase inhibitor, are mainly formed by aldehyde oxidase and CYP3A4 / 3A5 in human liver S9 and hepatoc

NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF

The present invention provides a method capable of industrially producing a target product, i.e., a compound represented by the aforementioned formula (I) or a salt thereof, which is useful for preventing and treating cerebrovascular disorders such as cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral edema, particularly for preventing and treating glaucoma, at high yield even on a large scale without imposing a negative impact on the environment. The present invention provides a method for producing a compound represented by formula (I) or a salt thereof, wherein the method comprises a step of reacting a compound represented by formula (III) or a salt thereof with a compound represented by formula (II) in the presence of at least one solvent selected from the group consisting of a nitrile solvent, an amide solvent, a sulfoxide solvent, and a urea solvent, and a base.

A practical synthesis of (S)- tert -butyl 3-methyl-1,4-diazepane-1- carboxylate, the key intermediate of rho-kinase inhibitor K-115

A practical synthesis of (S)-tert-butyl 3-methyl-1,4-diazepane-1- carboxylate has been established for supplying this key intermediate of Rho-kinase inhibitor K-115 in a multikilogram production. The chiral 1,4-diazepane was constructed by intramolecular Fukuyama-Mitsunobu cyclization of a N-nosyl diamino alcohol starting from the commercially available (S)- or (R)-2-aminopropan-1-ol. In the same manner, an enantiomeric pair of a structural isomer were prepared for demonstration of the synthetic utility.