1360622-01-0

Upstream product

• 1242270-11-6 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-nitro-benzoic acid amide 
• 1242270-09-2 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide 
• 1218943-32-8 trans-4-trifluoromethylcyclohexanamine hydrochloride 
• 933781-52-3 trans-4-(trifluoromethyl)cyclohexanecarboxamide 
• 1360624-07-2 N-(3-nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide 
• 1360624-05-0 3-nitro-2,4-dichloro-benzylamine 
• 1360624-03-8 N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide 
• 1360624-01-6 N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide 
• 1242269-83-5 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide 
• 1360623-99-9 N-(3-amino-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide 
• 1360623-95-5 3-amino-2,4-dichloro-benzamide 
• 50917-27-6 3-acetamido-2,4-dichlorobenzoic acid 
• 1242270-10-5 2-fluoro-4-methylamino-5-nitro-benzoic acid 
• 934330-05-9 trans-4-(trifluoromethyl)cyclohexanecarbonyl chloride 

Relevant academic research and scientific papers

NEW COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.

NEW COMPOUNDS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.