1360895-65-3Relevant academic research and scientific papers
A versatile thiouronium-based solid-phase synthesis of 1,3,5-triazines
Kong, Kah Hoe,Tan, Chong Kiat,Lin, Xijie,Lam, Yulin
, p. 1476 - 1486 (2012/03/26)
A thiouronium-based solidphase synthesis of a 1,3,5-triazine scaffold has been developed. The key feature of the synthesis is the use of a readily accessible solid-supported thiouronium salt as a primary precursor for the stepwise assembly of the 1,3,5-tri-azine substrate. The sulfur linker employed in the synthesis is stable under both acidic and basic conditions and is versatile enough to provide access to monocyclic, bicyclic, and spirocyclic compounds with the 1,3,5-triazine scaffold. By using this synthetic strategy, a representative set of 79 compounds containing the 1,3,5-triazine scaffold were prepared.
