136092-35-8

Upstream product

• 136092-34-7 (2R,5R)-2-Butyl-5-((E)-4-oxo-pent-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1034498-80-0 (2R,5S)-(+)-2-n-butyl-5-(4-pentenyl)pyrrolidine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 136092-32-5 (2R,5R)-2-Butyl-5-(2-hydroxy-ethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 136092-33-6 (2R,5R)-2-Butyl-5-(2-oxo-ethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 136092-37-0 (5R)-Z-Methyl (5-butyl-2-pyrrolidinylidene)acetate 
• 136092-36-9 ((R)-5-Butyl-pyrrolidin-2-yl)-acetic acid methyl ester 
• 136092-38-1 (R)-5-n-Butyl-2-pyrrolidinone 
• 136092-31-4 2-((R)-5-Butyl-pyrrolidin-2-yl)-ethanol 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 

Relevant academic research and scientific papers

Enantioselective syntheses of (-)- and (+)-monomorine I

(Chemical Equation Presented) A concise enantioselective total synthesis of unnatural (-)-monomorine I has been achieved starting from lactam 2 in 54% overall yield. Natural (+)-monomorine I was also synthesized.

Facile preparation of deoxybenzoins via a novel synthesis of enamines

N-Aryl(or alkyl)-N-benzylanilines and benzylideneaniline condense in N,N-dimethylformamide in the presence of potassium t-butoxide to give enamines in good yields. Hydrolysis of the latter give deoxybenzoin with 100% conversion.

Total synthesis of (+) monomorine I from chiral cyclic β-enamino estrer

We describe the total synthesis of (+) monomorine I 1 and the preparation of cis-2,5-disubstituted functionalized pyrrolidines via cyclic β-enamino esters 4, starting from (S)-pyroglutamic acid.