1360946-47-9Relevant academic research and scientific papers
A traceless vascular-targeting antibody-drug conjugate for cancer therapy
Bernardes, Go?alo J. L.,Casi, Giulio,Trüssel, Sabrina,Hartmann, Isabelle,Schwager, Kathrin,Scheuermann, J?rg,Neri, Dario
, p. 941 - 944 (2012)
Right on target: A chemically defined vascular-targeting antibody-drug conjugate (ADC) that offers comprehensive tumor coverage has been developed. When injected intravenously, this ADC potently inhibited tumor growth in a syngeneic immunocompetent model of murine cancer which cannot be cured by conventional cytotoxic agents. Copyright
BIOLOGICAL MATERIALS AND USES THEREOF
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Page/Page column 81, (2016/06/06)
The invention provides compounds comprising a therapeutic agent coupled to a carrier molecule, with a minimum coupling ratio of 5: 1; wherein the carrier molecule is (i) an antibody fragment or derivative thereof or (ii) an antibody mimetic or derivative thereof; and wherein the therapeutic agents are coupled onto a lysine amino acid residue; and further wherein the therapeutic agent is not a photosensitising agent. There is also provided uses, methods relating to such compounds, as well as processes for their manufacture.
