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Upstream product

• 1456905-28-4 C₂₁H₁₄N₂ 
• 1456905-26-2 C₁₃H₉BrN₂ 
• 536-74-3 phenylacetylene 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 75586-32-2 2-phenylethynylbenzaldehyde p-toluenesulphonylhydrazone 

Relevant academic research and scientific papers

A facile route to H -Pyrazolo[5,1- A ]isoquinolines through a multicomponent reaction of 2-Alkynylbenzaldehyde, sulfonylhydrazine, and benzyne

A facile and efficient route for the generation of H-pyrazolo[5,1-a] isoquinolines via a silver triflate catalyzed three-component reaction of 2-alkynylbenzaldehyde, tosylhydrazine, and benzyne is reported. This reaction proceeds smoothly under mild conditions with high efficiency. Georg Thieme Verlag Stuttgart New York.

Cu-Catalyzed alkynylation-cyclization cascade for the construction of the pyrazolo[5,1-a]isoquinoline skeleton

A Cu-catalyzed Sonogashira-type coupling of 3-(2-bromophenyl)pyrazoles with terminal alkynes combined with a subsequent electrophilic cyclization in the same pot was developed to afford pyrazolo[5,1-a]isoquinolines. The transformation proceeds without the necessity of using Pd or ligands, while an Ag additive is beneficial. The Royal Society of Chemistry 2013.

Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: A potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines

The aryne [3 + 2] cycloaddition process with pyridinium imides breaks the aromaticity of the pyridine ring. By equipping the imide nitrogen with a sulfonyl group, the intermediate readily eliminates a sulfinate anion to restore the aromaticity, leading to the formation of pyrido[1,2-b]indazoles. The scope and limitation of this reaction are discussed. As an extension of this chemistry, N-tosylisoquinolinium imides, generated in situ from N′-(2-alkynylbenzylidene)-tosylhydrazides via an AgOTf-catalyzed 6-endo-dig electrophilic cyclization, readily undergo aryne [3 + 2] cycloaddition to afford indazolo[3,2-a]-isoquinolines in the same pot, offering a highly efficient route to these potential anticancer agents.