136138-52-8

Upstream product

• 456-22-4 4-Fluorobenzoic acid 
• 615-43-0 2-iodophenylamine 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 397-54-6 2-(4-fluorophenyl)benzoxazole 
• 18600-51-6 2-(4-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 366-63-2 4-fluoro-N-phenylbenzamide 
• 1629-26-1 2-(4-fluorophenyl)-benzothiazole 
• 1415218-69-7 4-fluoro-N-[2-(phenylethynyl)phenyl]benzamide 
• 136138-45-9 [2-(4-Fluoro-benzoyl)-phenyl]-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Dibrominative Spirocyclization of 2-Butynolyl Anilides: Synthesis of gem-Dibromospirocyclic Benzo[ d][1,3]oxazines and Their Application in the Synthesis of 4 H-Furo[3,2- b]indoles

The combination of catalytic aqueous hydrochloric acid (HCl) and N-bromosuccinimide (NBS) generated electrophilic bromine monochloride (BrCl), which readily induced spiroannulation of 2-alkynolyl anilides (n = 1-3) to form gem-dibromospirocyclic benzo[d][

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis

An ortho-amination, ipso-C-H arylation mediated by palladium/norbornene cooperative catalysis is reported. This reaction proceeds through a sequential intermolecular C-N bond formation process followed by intramolecular C-H activation of a tethered arene. The products, aminated phenanthridinones, were generated in moderate to good yields. This method is also applicable to the formation of dibenzazepinones.

Cu-catalyzed in situ generation of thiol using xanthate as a thiol surrogate for the one-pot synthesis of benzothiazoles and benzothiophenes

A new copper-catalyzed in situ generation of aryl thiolates strategy was successfully developed for the one-pot synthesis of substituted benzothiazoles from 2-iodoanilides using xanthate as a thiol precursor. A wide range of 2-iodoanilides with both electron-releasing and electron-withdrawing groups produced the corresponding benzothiazoles in good yields. Further, this one-pot protocol was successfully utilized for the synthesis of a potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzo[d]thiazole (PMX 610). Finally, the copper-catalyzed in situ generation of aryl thiolates strategy was successfully applied for the domino synthesis of substituted benzothiophenes from o-haloalkynyl benzenes using xanthate as a thiol precursor.

Iodine-catalyzed, stereo- and regioselective synthesis of 4-arylidine-4H-benzo[d][1,3]oxazines and their applications for the synthesis of quinazoline 3-oxides

4-Benzylidene-2-aryl-4H-benzo[d][1,3] oxazines have been synthesized with high stereoselectivity and regioselectivities from 2-alkynylbenzamides in the presence of a catalytic amount of I2. In the reaction mechanism, iodine plays a key role in

Role of Hetero-halogen (F · · · X, X = Cl, Br, and I) or homo-halogen (X · · · X, X = F, Cl, Br, and I) interactions in substituted benzanilides

A series of halogen-substituted benzanilides have been synthesized and characterized, and crystallization studies directed toward generation of polymorphs have been performed to delineate the importance of interactions involving halogens. The effect of ha