1629-26-1

Usage

Uses

Used in Pharmaceutical Industry:
BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)is used as a key intermediate in the synthesis of various pharmaceuticals for its potential antitumor, antiviral, and antimicrobial properties. The presence of the fluorine substituent enhances its biological activity, making it a promising candidate for the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)is used as a building block for the development of new agrochemicals with improved efficacy and selectivity. Its potential antimicrobial and antiviral activities make it a valuable component in the creation of novel pesticides and fungicides.
Used in Dye Industry:
BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)is used as a component in the synthesis of various dyes due to its unique chemical properties. Its ability to absorb and emit light makes it suitable for use in the development of new dyes with specific color characteristics and applications.
Used in Organic Electronics:
In the field of organic electronics, BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)is used as a component in the fabrication of organic light-emitting diodes (OLEDs) and organic photovoltaic (OPV) devices. Its unique electronic properties and compatibility with other organic materials make it a valuable building block for the development of efficient and versatile electronic devices.

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 137-07-5 2-amino-benzenethiol 
• 1194-02-1 4-fluorobenzonitrile 
• 161891-29-8 (Z)-3-chloro-3-(4-fluorophenyl)acrylaldehyde 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 1765-93-1 4-fluoroboronic acid 
• 95-16-9 1,3-Benzothiazole 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1629-19-2 N-(4-Fluor-thiobenzoyl)-anilin 
• 459-57-4 4-fluorobenzaldehyde 
• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 456-22-4 4-Fluorobenzoic acid 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 100-52-7 benzaldehyde 

Downstream Products

• 940287-58-1 2-(4-fluoro-2-nitrophenyl)benzo[d]thiazole 

Relevant academic research and scientific papers

Orange phosphorescent Ir(III) complexes consisting of substituted 2-phenylbenzothiazole for solution-processed organic light-emitting diodes

Orange phosphorescent iridium(III) complexes, (DMBT)2Ir(acac) and (TBT)2Ir(acac), based on either 2-(3,4-dimethylphenyl)benzo[d]thiazole (DMBT) or 2-(4-(trimethylsilyl)phenyl)benzo[d]thiazole (TBT) as the cyclometalated main ligands

Synthesis of benzimidazoles/benzothiazoles by using recyclable, magnetically separable nano-Fe2O3 in aqueous medium

An efficient, simple, ecofriendly and cost-effective method has been developed for the synthesis of benzimidazole/benzothiazole derivatives by a two-component reaction, involving 1,2-diamino benzene/2-amino thiophenol and substituted aromatic aldehydes us

Microwave-induced solvent-free synthesis of 2-arylbenzothiazoles using p-TsOH

A simple and efficient procedure has been developed for the synthesis of 2-arylbenzothiazoles by a one-pot reaction of o-aminothiophenol with β-chlorocinnamaldehydes using p-TsOH under microwave irradiation.

An efficient palladium catalyzed synthesis of 2-arylbenzothiazoles

A novel and convergent palladium catalyzed synthesis of 2-arylbenzothiazoles has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 2-bromobenzothiazole with aryl boronic acids to provide a variety of 2-arylbenzothiazole derivatives in good yield. The synthetic utility of this methodology is demonstrated by the synthesis of 2-(4-aminophenyl)-6-methoxybenzothiazole, a PET probe precursor for the in vivo imaging of Alzheimer's disease.

Graphene oxide-catalyzed synthesis of benzothiazoles with amines and elemental sulfur via oxidative coupling strategy of amines to imines

The graphene oxide-catalyzed coupling and cyclization reactions of primary amines with elemental sulfur was developed to afford various optically property benzothiazoles. This coupling and cyclization strategies proceeded under the oxidant system graphene oxide/O2 and constructed carbon-heteroatom (N, S) bonds with amines and elemental sulfur. Due to benzothiazoles as common chromophores, these products exhibited intriguing fluorescence properties, including outstanding Stokes shifts (up to 161 nm) and quantum yields (up to 74%). Utilizing the products’ unique fluorescence response in different solvents, β-naphthothiazole 4a showed excellent aggregation-induced emission properties in 1,2-dichloroethane, which was 60 times higher than in tetrahydrofuran.

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

Fast and high-efficiency synthesis of 2-substituted benzothiazoles via combining enzyme catalysis and photoredox catalysis in one-pot

An efficient and green method, combining enzymatic and visible-light catalysis for synthesis of the widely applicable 2-substituted benzothiazoles, has been developed. This method features a relay catalysis protocol consisting of biocatalytic promiscuity

Ultrasound-assisted efficient and green synthesis of 2-substituted benzothiazoles under solvent-free condition using recyclable sulfated tungstate

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the synthesis of 2-substituted benzothiazoles. The corresponding benzothiazoles were obtained using a condensation reaction of 2-aminothiophenol with various aldehydes under ultrasound irradiation at room temperature. Various functional groups on the 2-aminothiophenol as well as on the aldehydes were tolerated to provide 2-substituted benzothiazoles derivatives in excellent yields. The faster reaction rate, solvent-free or mild reaction conditions, wide functional group compatibility, excellent yields, easy work-up procedure, and excellent catalyst recyclability are the advantages of this protocol. These advantages make this process more practicable, cost-effective, and environmentally benign.

Ionic liquid-immobilized hybrid nanomaterial: an efficient catalyst in the synthesis of benzimidazoles and benzothiazoles via anomeric-based oxidation

Abstract: In this study, a novel ionic liquid immobilized on silica-coated cobalt-ferrite magnetic nanoparticles. This novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was characterized by various microscopic and spectroscopic techniques including Fourier transformation infrared spectroscopy (FT–IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (SEM), the electron-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA/DTG). The catalytic activity of prepared nanomaterial was considered in the synthesis of the benzothiazole and benzimidazole derivatives. This method has several advantages such as good to excellent yields, short reaction times, solvent-free and environmentally-benign conditions, and simple work-up. Besides, nanocatalyst can be easily separated from the reaction mixture with the external magnetic field and reused several times without any loss of its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].

Synthesis of benzothiazoles using fluorescein as an efficient photocatalyst under visible light

This work reports a novel and efficient method for the synthesis of benzothiazoles using 2-aminothiophenol derivatives in conjunction with aromatic aldehyde as starting materials via visible-light-induced condensation cyclization. Utilizing fluorescein as the photocatalyst and blue LED lamp as the light source, the reaction proceeds in the presence of a molecular oxygen atmosphere without the need for metal catalyst or an additional oxidant. Significantly, this method exhibits good tolerance in substrates, and a variety of 2-aminothiophenol derivatives and aromatic aldehyde are amenable to producing the corresponding benzothiazoles in high to excellent yields.