1629-26-1

Basic information

• Product Name: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-
• Synonyms: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-;2-(4-Fluoro-phenyl)-benzothiazole;2-(4-fluorophenyl)-1,3-benzothiazole
• CAS NO: 1629-26-1
• Molecular Formula: C₁₃H₈FNS
• Molecular Weight: 229.2727232
• Mol File: 1629-26-1.mol
• Article Data: 172

Chemical Properties

• Boiling Point: 352.1 °C at 760mmHg
• Flash Point: 166.7 °C
• Appearance: /
• Density: 1.304 g/cm³
• CAS DataBase Reference: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(1629-26-1)
• EPA Substance Registry System: BENZOTHIAZOLE, 2-(4-FLUOROPHENYL)-(1629-26-1)

Safety Data

• Hazardous Substances Data: 1629-26-1(Hazardous Substances Data)

Usage

General Description

Benzothiazole, 2-(4-fluorophenyl)- is a chemical compound with the molecular formula C14H9FNS. It is a heterocyclic organic compound that is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Benzothiazole derivatives have been studied for their potential antitumor, antiviral, and antimicrobial activities. The presence of a fluorine substituent on the phenyl ring of benzothiazole can greatly influence its physicochemical and biological properties, making it a valuable building block for the development of new drugs and materials. Furthermore, 2-(4-fluorophenyl)benzothiazole has also found application in the field of organic electronics as a component in the fabrication of organic light-emitting diodes and organic photovoltaic devices.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 137-07-5 2-amino-benzenethiol 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 1765-93-1 4-fluoroboronic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 100-52-7 benzaldehyde 
• 352-32-9 p-fluorotoluene 
• 403-43-0 4-fluorobenzoyl chloride 
• 62-53-3 aniline 
• 140-75-0 para-fluorobenzylamine 
• 824-75-9 p-fluorobenzamide 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 940287-58-1 2-(4-fluoro-2-nitrophenyl)benzo[d]thiazole 

Relevant articles and documents

Orange phosphorescent Ir(III) complexes consisting of substituted 2-phenylbenzothiazole for solution-processed organic light-emitting diodes

Orange phosphorescent iridium(III) complexes, (DMBT)2Ir(acac) and (TBT)2Ir(acac), based on either 2-(3,4-dimethylphenyl)benzo[d]thiazole (DMBT) or 2-(4-(trimethylsilyl)phenyl)benzo[d]thiazole (TBT) as the cyclometalated main ligands

Microwave-induced solvent-free synthesis of 2-arylbenzothiazoles using p-TsOH

A simple and efficient procedure has been developed for the synthesis of 2-arylbenzothiazoles by a one-pot reaction of o-aminothiophenol with β-chlorocinnamaldehydes using p-TsOH under microwave irradiation.

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles

The synthesis of 2-substituted benzothiazoles has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.