1361397-05-8

Upstream product

• 61150-57-0 2-bromo-4-fluorobenzyl bromide 
• 61150-58-1 2-(2-bromo-4-fluorophenyl)acetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 1250021-16-9 1-(2-bromo-4-fluorophenyl)-2-propanone 
• 1362477-26-6 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine 
• 1242533-20-5 4-(2-bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine 
• 1449316-63-5 3-(2-bromo-4-fluorophenyl)-4-[(2-chloro-6-fluorophenyl)amino]-4-(methylthio)-3-buten-2-one 

Relevant academic research and scientific papers

Construction of 1,3-Dithio-Substituted Tetralins by [1,5]-Alkylthio Group Transfer Mediated Skeletal Rearrangement

A novel skeletal rearrangement involving a [1,5]-alkylthio group transfer/cyclization sequence is described. Treatment of benzylidene malonates having a thioketal moiety at the homobenzyl position with a catalytic amount of Sc(OTf)3 afforded alkylthio group rearranged adducts in good chemical yields. Detailed investigation of the reaction mechanism revealed that an intramolecular conjugate addition/ring opening sequence (not through-space transfer) is the key to achieving this reaction.

Copper-catalysed: N -arylation of 5-aminopyrazoles: A simple route to pyrazolo[3,4- b] indoles

A copper-catalysed intramolecular N-arylation of 5-aminopyrazoles is demonstrated for the first time. Highly substituted pyrazolo[3,4-b]indoles are synthesized. In particular, the indole core is decorated with halogens and alkyl and methoxy groups. Furthermore, a selective N-arylation of unsymmetrical diaryl bromide containing pyrazoles is exemplified, resulting in valuable pyrazolo[1,5-a]benzimidazoles. This journal is

FUNGICIDAL PYRAZOLE MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, (1) wherein R1 is H or halogen; R2 is H or halogen; R3 is halogen; R4 is halogen or CH3; and R5 is halogen, cyano, CH3 or C1-C2 alkoxy; and (b) at least one additional fungicidal compound selected from those disclosed herein. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition.

FUNGICIDAL PYRAZOLE MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula (1), N-oxides, and salts thereof, wherein R1 is F, C1 or Br; R2 is H or F; and R3 is C1 or Br; and (b) at least one fungicidal compound selected from (b1) through (b13) as disclosed herein. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed are process intermediate compounds useful for preparing compounds of Formula (1).

FUNGICIDAL PYRAZOLES AND THEIR MIXTURES

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula (1), N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as