1361525-14-5Relevant academic research and scientific papers
Asymmetric indoline synthesis via intramolecular aza-Michael addition mediated by bifunctional organocatalysts
Miyaji, Ryota,Asano, Keisuke,Matsubara, Seijiro
supporting information, p. 3658 - 3661 (2013/08/23)
A novel method for the asymmetric synthesis of 2-substituted indolines, employing bifunctional amino(thio)urea catalysts, was developed. The reaction proceeded via an intramolecular aza-Michael addition mediated by activation through hydrogen bonding. The
Enantioselective synthesis of 2-substituted pyrrolidines via domino cross metathesis/intramolecular aza-Michael addition
Liu, Hanbin,Zeng, Chuanqi,Guo, Jiajia,Zhang, Mengyao,Yu, Shouyun
, p. 1666 - 1668 (2013/03/13)
A highly enantioselective intramolecular aza-Michael addition with enone carbamates catalyzed by chiral Bronsted acids was developed. A domino cross metathesis/aza-Michael addition for the preparation of 2-substituted pyrrolidines or benzopyrrolidines was also explored. The reactions described here provide an efficient asymmetric protocol for enantio-enriched heterocycles, especially 2-substituted pyrrolidines.
