1361537-92-9Relevant academic research and scientific papers
Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles
Sheng, Heyun,Su, Jianke,Li, Xin,Li, Xue,Song, Qiuling
supporting information, p. 7781 - 7786 (2021/10/25)
We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluo
Hexafluoroisopropanol-Mediated Redox-Neutral α-C(sp3)-H Functionalization of Cyclic Amines via Hydride Transfer
Shen, Yao-Bin,Wang, Lin-Xuan,Sun, Yun-Ming,Dong, Feng-Ying,Yu, Liping,Liu, Qing,Xiao, Jian
, p. 1915 - 1926 (2020/02/04)
Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)-H functionalization of cyclic amines via the cascade [1,5]-hydride transfer/cyclization strategy. A wide range of cyclic amines are functionalized
Direct Intermolecular C-H Functionalization Triggered by 1,5-Hydride Shift: Access to N-Arylprolinamides via Ugi-Type Reaction
Zhen, Le,Wang, Jiankun,Xu, Qing-Long,Sun, Hongbin,Wen, Xiaoan,Wang, Guangji
supporting information, p. 1566 - 1569 (2017/04/13)
A novel Ugi-type reaction triggered by 1,5-hydride shift has been established, giving access to N-arylprolinamides and related compounds in high atom economy and good yields. This is an example of a two starting material-three component reaction. The benz
HETEROCYCLIC DERIVATIVES AS RORGAMMA MODULATORS
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Page/Page column 57, (2016/07/27)
The present invention provides novel compounds of formula (I) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, fibrotic diseases, or cholestatic diseases.
N-fused indolines through non-carbonyl-stabilized rhodium carbenoid C-H insertion of N-aziridinyl imines
Mahoney, Stuart J.,Fillion, Eric
supporting information; experimental part, p. 68 - 71 (2012/02/04)
Under rhodium catalysis, N-aziridinyl imines provided access to N-fused indolines through non-carbonyl-stabilized rhodium carbenoid C-H insertion. The utility of this methodology for the synthesis of architecturally complex heterocycles was further demonstrated by an expedient total synthesis of ( ±)-cryptaustoline (see scheme). Copyright
