13616-10-9

Usage

Uses

Used in Organic Synthesis:
1H-Benzimidazole,2-(dimethoxymethyl)-(9CI) is used as a synthetic intermediate for the preparation of various organic compounds. The presence of methoxy groups allows for the formation of other functional groups, making it a versatile building block in organic synthesis.
Used in Medicinal Chemistry:
1H-Benzimidazole,2-(dimethoxymethyl)-(9CI) is used as a potential candidate for the development of new drugs due to its benzimidazole core. Benzimidazole derivatives have been studied for their antiviral and anticancer properties, and further research into the biological activity of 1H-Benzimidazole,2-(dimethoxymethyl)-(9CI) may lead to the discovery of new therapeutic agents.
Used in Pharmaceutical Industry:
1H-Benzimidazole,2-(dimethoxymethyl)-(9CI) is used as a starting material for the synthesis of pharmaceutical compounds. Its unique structure and potential medicinal properties make it a valuable component in the development of new drugs for various therapeutic applications.
Used in Chemical Research:
1H-Benzimidazole,2-(dimethoxymethyl)-(9CI) is used as a research tool in the study of benzimidazole chemistry and its potential applications. Its unique structure and properties make it an interesting subject for further investigation and understanding of the reactivity and behavior of benzimidazole derivatives.

Upstream product

• 64931-89-1 4-p-tolyl-1H-benzo[4,5]imidazo[1,2-d][1,2,4]oxadiazine 
• 67-56-1 methanol 
• 3314-30-5 1H-benzoimidazole-2-carboxaldehyde 
• 64931-86-8 4-phenyl-1H-<1,2,4>oxadiazino<4,5-a>benzimidazole 
• 51673-84-8 dimethoxyacetaldehyde 
• 95-54-5 1,2-diamino-benzene 

Relevant academic research and scientific papers

An efficient one-pot two catalyst system in the construction of 2-substituted benzimidazoles: Synthesis of benzimidazo[1,2-c]quinazolines

The benzimidazole core is a common moiety in a large number of natural products and pharmacologically active small molecules. The synthesis of novel benzimidazole derivatives remains a main focus in medicinal research. In continuation of the efforts towards Ce(iii) catalysts for organic transformations, we observed for the first time the activity of the iodide ion and copper cation in activating CeCl3·7H2O in the selective formation of prototypical 2-substituted benzimidazoles. The one-pot CeCl3·7H2O-CuI catalytic system procedure includes the cyclo-dehydrogenation of aniline Schiff's bases, generated in situ from the condensation of 1,2-phenylenediamine and aldehydes, followed by the oxidation with iodine, which works as a hydrogen sponge. Mild reaction conditions, good to excellent yields, and clean reactions make the procedure a useful contribution to the synthesis of biologically active fused heterocycles containing benzimidazoquinazolines.

Photolysis of 4-Aryl-1H-oxadiazinobenzimidazoles

Photolysis of 4-aryl-1H-oxadiazinobenzimidazoles (I) in alcohols yields the corresponding benzimidazole-2-carboxaldehyde dialkyl acetals (III, R=CH3, C2H5) and aryl amides (IV) instead of the expected 1-oxo derivatives (II).A plausible mechanism involving the intermediacy of benzimidazole-2-carboxaldehyde (V) and aryl nitrile (VI) has been proposed.