1362048-96-1Relevant academic research and scientific papers
Tandem Chiral Cu(II) Phosphate-Catalyzed Deoxygenation of Nitrones/Enantioselective Povarov Reaction with Enecarbamates
Gelis, Coralie,Levitre, Guillaume,Guérineau, Vincent,Touboul, David,Neuville, Luc,Masson, Géraldine
, p. 5151 - 5155 (2019)
A new catalytic enantioselective tandem deoxygenation/aza-Diels-Alder reaction of nitrones with enecarbamates was serendipitously discovered in the presence of chiral copper(II) diphosphate complexes. This process affords a wide range of 4-aminotetrahydroquinolines in respectable yields under mild conditions with good to excellent ee values.
Chiral Phosphoric Acid-Catalyzed Enantioselective Construction of 2,3-Disubstituted Indolines
Ma, Wei-Yang,Gelis, Coralie,Bouchet, Damien,Retailleau, Pascal,Moreau, Xavier,Neuville, Luc,Masson, Géraldine
supporting information, p. 442 - 448 (2021/01/26)
Highly enantio- and regioselective (3 + 2) formal cycloaddition of β-substituted ene- and thioenecarbamates as well as cyclic enamides with quinone diimides catalyzed by a BINOL- and SPINOL-derived phosphoric acid is reported. A wide variety of 2,3-disubstituted 2-aminoindolines, including polycyclic ones, were prepared in generally high yields (up to 98%) with moderate to complete diastereoselectivities and in most cases excellent enantioselectivities (up to 99% ee).
