136226-78-3Relevant academic research and scientific papers
One-step preparation of 1-substituted tetrahydroisoquinolines via the Pictet-Spengler reaction using zeolite catalysts
Hegedüs, Adrienn,Hell, Zoltán
, p. 8553 - 8555 (2004)
A new, one-step variation of the Pictet-Spengler reaction has been elaborated using a small pore size zeolite as the catalyst. A new, environmentally friendly variation of the Pictet-Spengler reaction has been elaborated using a small pore size zeolite. The easily separable and recyclable catalyst provided high conversions and a shorter reaction time than the classical acetic acid or trifluoroacetic acid.
Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-methyl-D-aspartate antagonists
Ohkubo, Mitsuru,Kuno, Atsushi,Katsuta, Kiyotaka,Ueda, Yoshiko,Shirakawa, Kiyoharu,Nakanishi, Hajime,Nakanishi, Isao,Kinoshita, Takayoshi,Takasugi, Hisashi
, p. 95 - 102 (2007/10/03)
A series of 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for anticonvulsant activity against intracerebro-ventriculas (i.c.v.) N-methyl-D-aspartate (NMDA)-induced seizures in mice. Among these compounds, (+)-1-methyl-1-phenyl-
