13626-17-0

Basic information

• Product Name: 3,5-DIBROMO-4-CHLOROPYRIDINE
• Synonyms: 3,5-DIBROMO-4-CHLOROPYRIDINE;4-Chloro-3,5-dibroMopyridine;13626-17-0
• CAS NO: 13626-17-0
• Molecular Formula: C₅H₂Br₂ClN
• Molecular Weight: 271.34
• Mol File: 13626-17-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 256.4±35.0 °C(Predicted)
• Appearance: /
• Density: 2.136±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.30±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIBROMO-4-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMO-4-CHLOROPYRIDINE(13626-17-0)
• EPA Substance Registry System: 3,5-DIBROMO-4-CHLOROPYRIDINE(13626-17-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 13626-17-0(Hazardous Substances Data)

Usage

General Description

3,5-Dibromo-4-chloropyridine is a chemical compound with the molecular formula C5H2Br2ClN. It is a pyridine derivative that contains two bromine atoms and one chlorine atom attached to a central pyridine ring. 3,5-DIBROMO-4-CHLOROPYRIDINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the manufacturing of dyes and pigments. 3,5-Dibromo-4-chloropyridine is a highly reactive and versatile chemical with a wide range of applications in the pharmaceutical and chemical industries. It is important to handle this compound with care due to its toxic, corrosive, and flammable properties.

Upstream product

• 626-64-2 pyridin-4-ol 
• 84539-34-4 4-amino-3,5-dibromopyridine 
• 861019-41-2 3,5-dibromo-4-chloro-pyridine-2-carboxylic acid methyl ester 
• 858852-20-7 3,5-dibromo-4-hydroxy-pyridine-2-carboxylic acid 
• 108-96-3 4-pyridone 
• 28419-11-6 3,5-dibromo-1,4-dihydropyridin-4-one 
• 2402-99-5 3,5-dibromopyridine-N-oxide 
• 7791-25-5 sulfuryl dichloride 
• 25813-25-6 3,5-dibromo-4-hydroxypyridine 
• 698393-07-6 3,5-dibromo-4-chloro-pyridine-2-carboxylic acid 

Downstream Products

• 63905-95-3 3,5-dibromo-pyridine-4-thiol 
• 872273-27-3 3,5-dibromopyridine-4-sulfonic acid 
• 1256821-58-5 7-bromo-1H-pyrazolo[4,3-c]pyridine 
• 1060802-24-5 5-bromo-4-chloro-pyridine-3-carbaldehyde 
• 25813-24-5 3,5-dibromo-4-methoxypyridine 

Relevant articles and documents

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small molecule modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biological validation experiments indicated that the mode of action was upstream or independent of mTOR.

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

4-(N,N-dimethylamino)pyridine-embedded nanoporous conjugated polymer as a highly active heterogeneous organocatalyst

We report herein for the first time the incorporation of a versatile organocatalyst, 4-(N,N-dimethylamino)pyridine (DMAP), into the network of a nanoporous conjugated polymer (NCP) by the "bottom-up" approach. The resulting DMAP-NCP material possesses highly concentrated and homogeneously distributed DMAP catalytic sites (2.02 mmol g-1). DMAP-NCP also exhibits enhanced stability and permanent porosity due to the strong covalent linkage and the rigidity of the "bottom-up" monomers. As a result, DMAP-NCP shows excellent catalytic activity in the acylation of alcohols with yields of 92-99 %. The DMAP-NCP catalyst could be easily recovered from the reaction mixture and reused in at least 14 consecutive cycles without measurable loss of activity. Moreover, the catalytic acylation reaction could be performed under neat and continuous-flow conditions for at least 536 h of continuous work with the same catalyst activity. Copyright