136262-55-0Relevant academic research and scientific papers
Toward the development of a general chiral auxiliary. A total synthesis of (+)-tetronolide via a tandem ketene-trapping [4 + 2] cycloaddition strategy
Boeckman Jr., Robert K.,Shao, Pengcheng,Wrobleski, Stephen T.,Boehmler, Debra J.,Heintzelman, Geoffrey R.,Barbosa, Antonio J.
, p. 10572 - 10588 (2007/10/03)
A highly convergent, enantioselective total synthesis of the aglycone of the tetrocarcins, (+)-tetronolide, is described. The synthesis highlights the use of several new methods, including camphor auxiliary-directed asymmetric alkylation and the enantiose
Studies directed toward the total synthesis of tetronolide 1. An enantioselective synthesis of the octahydronaphthalene unit
Boeckman Jr., Robert K.,Barta, Thomas E.,Nelson, Scott G.
, p. 4091 - 4094 (2007/10/02)
An efficient enantioselective route to the octahydronaphthalene unit present in tetronolide (1), the stereochemically complex aglycone common to the tetrocarcins, a novel group of antitumor substances, is described. The sequence employs the intramolecular
