136265-64-0

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-(2-BENZOYLHYDRAZINO)-1,3-THIAZOLE-4-CARBOXYLATE is used as a potential pharmaceutical candidate for various applications due to its thiazole ring, which is found in many biologically active compounds. It may have antimicrobial, antiviral, and anticancer properties, though further research and testing are needed to confirm its specific uses and potential benefits.
Used in Medicinal Chemistry:
ETHYL 2-(2-BENZOYLHYDRAZINO)-1,3-THIAZOLE-4-CARBOXYLATE is used as a compound of interest in the field of medicinal chemistry and drug development. Its unique structure and potential biological activities make it a promising candidate for the development of new therapeutic agents.

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 5351-66-6 benzoyl thiosemicarbazide 
• 67618-34-2 ethyl 2-hydrazinylthiazole-4-carboxylate 
• 98-88-4 benzoyl chloride 
• 136265-65-1 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole 

Downstream Products

• 136265-61-7 3-phenyl-5-ethoxycarbonylthiazolo<2,3-c>-1,2,4-triazole 
• 136265-65-1 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole 

Relevant academic research and scientific papers

SYNTHESIS AND PROPERTIES OF THIAZOLE HALOHYDRAZONES. 2. INTERACTION OF 2-α-CHLOROBENZYLIDENEHYDRAZINO-4-ETHOXY-CARBONYLTHIAZOLE WITH NUCLEOPHILES

In the interaction of 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole with nucleophiles, two competing reactions take place: 1) nucleophilic replacement of the chlorine atom to form the corresponding substitution product; 2) elimination of a hydrogen chloride molecule, concluding in cyclization of the intermediate nitrilimine to form 3-phenyl-5-ethoxycarbonylthiazolo-1,2,4-triazole.The direction taken by the interaction depends on the nature of the nucleophile and is determined primarily by the ratio of basicity and nucleophilicity of the agent.

Acylation and carbamoylation of 2-hydrazinothiazole derivatives. Identification of isomeric structures

Acylation and carbamoylation of 2-(arylmethylidenehydrazino)- and 2-(aroylhydrazino)thiazoles was performed, and structure of the products was established.

SYNTHESIS AND PROPERTIES OF THIAZOLE HALOHYDRAZONES. 1. SYNTHESIS AND INTERACTION OF 2-α-CHLOROBENZYLIDENEHYDRAZINO-4-ETHOXYCARBONYL-THIAZOLE WITH TRIETHYLAMINE IN THE PRESENCE OF DIPOLAROPHILES

In the interaction of 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole with triethylamine, a nitrilimine is formed as an intermediate that does not react with dipolarophiles, but rather undergoes intramolecular 1,5-dipolar cyclization to form 3-phe

CARBAMOYLATION OF 2-HYDRAZINO-4-ETHOXYCARBONYLTHIAZOLE AND ITS DERIVATIVES

The carbamoylation and thiocarbamoylation of 2-hydrazino-4-ethoxycarbonylthiazole and its derivatives were studied.Products of substitution only at the N2 atom of the hydrazino group are formed in the reaction of the hydrazinothiazole with isoc

SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES

The condensation of thiosemicarbazones with bromopyruvic acid gives thiazolylhydrazone hydrobromides, which were converted to the free bases.The question of the site of protonation was studied by PMR spectroscopy.The possibility of self-protonation in 4-carboxythiazolylhydrazone crystals is not excluded.The thiazolylhydrazones are brominated in the 5 position.Both cyclization to thiazolyltriazoles and the Chetteueya-Walker reaction are realized in the case of oxidation with lead tetraacetate.