136265-65-1

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 5351-66-6 benzoyl thiosemicarbazide 
• 136265-64-0 ethyl 2-(N'-benzoylhydrazino)thiazole-4-carboxylate 
• 98-88-4 benzoyl chloride 
• 67618-34-2 ethyl 2-hydrazinylthiazole-4-carboxylate 

Downstream Products

• 136265-61-7 3-phenyl-5-ethoxycarbonylthiazolo<2,3-c>-1,2,4-triazole 
• 136265-64-0 ethyl 2-(N'-benzoylhydrazino)thiazole-4-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS AND PROPERTIES OF THIAZOLE HALOHYDRAZONES. 1. SYNTHESIS AND INTERACTION OF 2-α-CHLOROBENZYLIDENEHYDRAZINO-4-ETHOXYCARBONYL-THIAZOLE WITH TRIETHYLAMINE IN THE PRESENCE OF DIPOLAROPHILES

In the interaction of 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole with triethylamine, a nitrilimine is formed as an intermediate that does not react with dipolarophiles, but rather undergoes intramolecular 1,5-dipolar cyclization to form 3-phe

SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES

The condensation of thiosemicarbazones with bromopyruvic acid gives thiazolylhydrazone hydrobromides, which were converted to the free bases.The question of the site of protonation was studied by PMR spectroscopy.The possibility of self-protonation in 4-carboxythiazolylhydrazone crystals is not excluded.The thiazolylhydrazones are brominated in the 5 position.Both cyclization to thiazolyltriazoles and the Chetteueya-Walker reaction are realized in the case of oxidation with lead tetraacetate.