136279-23-7

Usage

Type of alcohol

Secondary alcohol

Halogen present

Bromine atom

Usage

Organic synthesis, pharmaceuticals

Structure

Phenyl ring with a bromomethyl group attached to the third carbon atom, and a propan-2-ol group

Application

Reagent in chemical reactions, building block in the synthesis of various organic compounds, important in medicinal chemistry and drug development.

Upstream product

• 67853-03-6 methyl 3-(hydroxymethyl)benzoate 
• 52178-50-4 Methyl 3-formylbenzoate 
• 75-16-1 methylmagnesium bromide 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 40912-34-3 3-(1-hydroxy-1-methylethyl)benzoic acid 
• 1346690-08-1 2-[3-(hydroxymethyl)phenyl]propan-2-ol 

Downstream Products

• 1418295-66-5 3-{(Z)-1-fluoro-2-[4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1-[3-(prop-1-en-2-yl)benzyl]-1H-pyrazole 
• 1571024-17-3 1-(3-(2-hydroxypropan-2-yl)benzyl)-5-(5-(4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one 
• 1571022-70-2 1-(3-(2-hydroxypropan-2-yl)benzyl)-5-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)pyridin-2(1H)-one 
• 302904-95-6 2-(3-Bromomethylphenyl)-2-triethylsilyloxy-propan 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

3-(Fluorovinyl)pyrazoles and their use

The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.