40912-34-3

Upstream product

• 535-77-3 m-cymene 
• 5208-37-7 8-hydroxy-m-cymene 
• 37847-24-8 3-acetyl-benzoic acid ethyl ester 
• 585-76-2 m-bromobenzoic acid 
• 67-64-1 acetone 
• 586-42-5 3-acetylbenzoic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 61776-64-5 3-(α-chloro-isopropyl)-benzoic acid 
• 105640-23-1 ethyl 3-isopropenylbenzoate 
• 61776-63-4 3-(α-chloro-isopropyl)-benzoic acid methyl ester 
• 1346690-08-1 2-[3-(hydroxymethyl)phenyl]propan-2-ol 
• 1448316-74-2 N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxypropan-2-yl)benzamide 
• 1418296-15-7 2-{3-[(3-{(Z)-1-fluoro-2-[4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]phenyl}propan-2-ol 
• 1418295-66-5 3-{(Z)-1-fluoro-2-[4-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl]vinyl}-5-methyl-1-[3-(prop-1-en-2-yl)benzyl]-1H-pyrazole 
• 136279-23-7 2-[3-(bromomethyl)phenyl]propan-2-ol 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Substituted phenylimidazopyrazoles and their use

The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.

HETEROCYCLIC CYTOKINE INHIBITORS

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory, anti-pain or anti-cancer agents. There are further provided m