136281-10-2Relevant academic research and scientific papers
Synthesis of 3,4-disubstituted quinolin-2-(1H)-ones via palladium-catalyzed decarboxylative arylation reactions
Carrer, Amandine,Brion, Jean-Daniel,Messaoudi, Samir,Alami, Mouad
, p. 2044 - 2054 (2013)
The Pd-catalyzed decarboxylative cross-coupling reaction of 4-substituted quinolin-2(1H)-one-3-carboxylic acids with (hetero)aryl halides is described. With palladium(II) bromide and triphenylarsine ligand as the catalyst system, a variety of 4-substituted 3-(hetero)aryl quinolin-2(1 H)-ones and related heterocycles, such as 4-substituted 3-arylcoumarins can be prepared in good to excellent yields. Copyright
Solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids via an intramolecular knoevenagel condensation
Watson, Brett T.,Christiansen, Gerda E.
, p. 9839 - 9840 (1998)
A solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids is described. The products are formed in a two-step synthesis in which ortho-aminophenones are first coupled to malonic acid bound to the Wang Resin followed by ring closure via an intramolecular Knoevenagel condensation.
Quinoline derivatives, their production and use
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, (2008/06/13)
A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g
