37393-68-3

Upstream product

• 93654-27-4 6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 105-53-3 diethyl malonate 
• 110-89-4 piperidine 
• 108-20-3 di-isopropyl ether 
• 1022-13-5 5-chloro-2-(methylamino)benzophenone 
• 141-52-6 sodium ethanolate 
• 1663-67-8 malonoyl dichloride 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 136281-10-2 6-chloro-1-methyl-2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 3,4-disubstituted quinolin-2-(1H)-ones via palladium-catalyzed decarboxylative arylation reactions

The Pd-catalyzed decarboxylative cross-coupling reaction of 4-substituted quinolin-2(1H)-one-3-carboxylic acids with (hetero)aryl halides is described. With palladium(II) bromide and triphenylarsine ligand as the catalyst system, a variety of 4-substituted 3-(hetero)aryl quinolin-2(1 H)-ones and related heterocycles, such as 4-substituted 3-arylcoumarins can be prepared in good to excellent yields. Copyright

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.

Quinoline derivatives, their production and use

A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g