Solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids via an intramolecular knoevenagel condensation

Article abstract of DOI:10.1016/S0040-4039(98)02246-1

A solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids is described. The products are formed in a two-step synthesis in which ortho-aminophenones are first coupled to malonic acid bound to the Wang Resin followed by ring closure via an intramolecular Knoevenagel condensation.