136289-54-8Relevant academic research and scientific papers
Cis -2,3-disubstituted cyclopropane 1,1-diesters in [3 + 2] annulations with aldehydes: Highly diastereoselective construction of densely substituted tetrahydrofurans
Yang, Gaosheng,Sun, Yongxian,Shen, Yue,Chai, Zhuo,Zhou, Shuangliu,Chu, Jiang,Chai, Jun
, p. 5393 - 5400 (2013)
A series of cis-2,3-disubstituted cyclopropane 1,1-diesters were examined in the AlCl3-promoted [3 + 2]-annulations with aldehydes. In this reaction, these cis-cyclopropanes displayed reactivities starkly different from their trans counterparts in terms of the high chemical yields (up to 98%) and provided the desired annulation products with excellent diastereomeric purity. This protocol provides a facile and highly stereoselective way to construct synthetically useful pentasubstituted tetrahydrofurans not easily accessible using other methods.
Vicarious nucleophilic substitution of hydrogen in electrophilic alkenes
Makosza,Kwast
, p. 5001 - 5018 (2007/10/02)
Carbanions containing leaving groups react in the presence of base with electrophilic alkenes giving products in which vinylic hydrogen is replaced with the carbanion moiety. They are formed via addition - β-elimination pathway analogous to the vicarious
