1363281-27-9

Basic information

• Product Name: VU 0409551
• Synonyms: VU 0409551;JNJ-46778212
• CAS NO: 1363281-27-9
• Molecular Formula: C₂₀H₁₇FN₂O₃
• Molecular Weight: 352.3589832
• EINECS: -0
• Mol File: 1363281-27-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 545.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.308±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.35±0.20(Predicted)
• CAS DataBase Reference: VU 0409551(CAS DataBase Reference)
• NIST Chemistry Reference: VU 0409551(1363281-27-9)
• EPA Substance Registry System: VU 0409551(1363281-27-9)

Safety Data

• Hazardous Substances Data: 1363281-27-9(Hazardous Substances Data)

Usage

Uses

VU 0409551 is an mGlu5 allosteric modulator.

Upstream product

• 86718-22-1 ethyl 4-amino-3-hydroxy-piperidine-1-carboxylate 
• 1363287-26-6 ethyl 3-oxo-4-[(2-phenoxyacetyl)amino]piperidine-1-carboxylate 
• 1363286-25-2 ethyl 2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridine-5-carboxylate 
• 1363286-22-9 6,7-dihydro-2-(hydroxymethyl)-oxazolo[5,4-c]pyridine-5(4H)-carboxylic acid ethyl ester 
• 1363286-19-4 2-formyl-6,7-dihydro-oxazolo[5,4-c]pyridine-5(4H)-carboxylic acid ethyl ester 
• 1363286-16-1 2-(1,2-dihydroxy-2-phenylethyl)-6,7-dihydro-oxazolo[5,4-c]pyridine-5(4H)-carboxylic acid ethyl ester 
• 1363286-13-8 6,7-dihydro-2-[(E)-2-phenylethenyl]-oxazolo[5,4-c]pyridine-5(4H)-carboxylic acid ethyl ester 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 86718-22-1 ethyl (3S,4R)-4-amino-3-hydroxypiperidine-1-carboxylate 
• 701-99-5 Phenoxyacetyl chloride 
• 1363286-28-5 2-(phenoxymethyl)-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine 
• 403-43-0 4-fluorobenzoyl chloride 
• 95629-02-0 ethyl 3-bromo-4-oxo-1-piperidinecarboxylate 

Downstream Products

• 1363281-54-2 2-[(3,4-difluorophenoxy)methyl]-5-(4-fluorobenzoyl)-4,5,6,7-tetrahydro-oxazolo[5,4-c]pyridine 
• 1363281-51-9 5-(4-fluorobenzoyl)-2-[(4-fluorophenoxy)methyl]-4,5,6,7-tetrahydro-oxazolo[5,4-c]pyridine 
• 1363281-45-1 5-(4-fluorobenzoyl)-2-[(3-fluorophenoxy)methyl]-4,5,6,7-tetrahydro-oxazolo[5,4-c]pyridine 
• 1363281-59-7 5-(4-fluorobenzoyl)-2-[(2-fluorophenoxy)methyl]-4,5,6,7-tetrahydro-oxazolo[5,4-c]pyridine 
• 1363287-54-0 {5-[(4-fluorophenyl)carbonyl]-4,5,6,7-tetrahydro[1,3]oxazolo[5,4-c]pyridin-2-yl}methanol 
• 1363283-34-4 5-[(4-fluorophenyl)carbonyl]-2-[(pyridin-4-yloxy)methyl]-4,5,6,7-tetrahydro[1,3]oxazolo[5,4-c]pyridine 
• 1363283-19-5 5-[(4-fluorophenyl)carbonyl]-2-[(pyridin-2-yloxy)methyl]-4,5,6,7-tetrahydro[1,3]oxazolo[5,4-c]pyridine 

Relevant articles and documents

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

Herein, we report the structure-activity relationship of a novel series of (2(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-yl(aryl)methanones as potent, selective, and orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5/su