136329-29-8

Basic information

• Product Name: Carbamic acid, [2-oxo-1-phenyl-2-(1-pyrrolidinyl)ethyl]-, phenylmethyl ester, (R)-
• CAS NO: 136329-29-8
• Molecular Formula: C20H22N2O3
• Molecular Weight: 338.406
• Mol File: 136329-29-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-oxo-1-phenyl-2-(1-pyrrolidinyl)ethyl]-, phenylmethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-oxo-1-phenyl-2-(1-pyrrolidinyl)ethyl]-, phenylmethyl ester, (R)-(136329-29-8)
• EPA Substance Registry System: Carbamic acid, [2-oxo-1-phenyl-2-(1-pyrrolidinyl)ethyl]-, phenylmethyl ester, (R)-(136329-29-8)

Safety Data

• Hazardous Substances Data: 136329-29-8(Hazardous Substances Data)

Upstream product

• 875-74-1 (R)-phenylglycine 
• 123-75-1 pyrrolidine 
• 17609-52-8 Z-D-phenylglycine 
• 501-53-1 benzyl chloroformate 
• 2935-35-5 (S)-2-phenylglycine 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 

Downstream Products

• 180305-85-5 (R)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 137581-63-6 (S)-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 1455472-41-9 (S)-benzyl (1-phenyl-2-(pyrrolidin-1-yl)ethyl)carbamate 
• 136328-89-7 (R)-2-(3,4-dichlorophenyl)-N-methyl-N-[1-phenyl-2-(pyrrolidin-1-yl)ethyl]acetamide 
• 116508-24-8 N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]-3,4-dichlorophenylacetamide 
• 190442-38-7 (R)-1-(N-isopropyl-2-phenylglycyl)pyrrolidine 
• 190442-37-6 (R)‐2‐amino‐2‐phenyl‐1‐(pyrrolidin‐1‐yl)ethan‐1‐one 
• 136329-39-0 (R)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 116508-51-1 (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 

Relevant articles and documents

Synthesis of Versatile Intermediates for Cyclopentanoid Natural Products via Enantioselective Deprotonation of Substituted Cyclopentene Oxide

Enantioselective deprotonation of cis and trans-3,4-epoxycyclopentan-1-ol derivatives with phenylglycine based ligand (R)-5 was studied.The cyclopentanoid intermediates were obtained in a maximum of 88percent ee.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Stereoselective reactions, 25. Enantioselective deprotonation of prochiral 4-substituted cyclohexanones by chiral chelated lithium amides

Enantioselective deprotonation of prochiral 4-substituted cyclohexanones (4a-d) by chiral chelated lithium amides (8a-k) in the presence of excess trimethylsilyl chloride was realized to give the corresponding chiral silyl enol ethers (6a-d) in up to 89% ee. It is shown that enantioselectivity of the reaction is dependent on the solvent used, but becomes almost independent on the solvent in the presence of HMPA. The sense of asymmetric induction can be correlated to the configuration at the chiral carbon bearing amide nitrogen of the lithium amide.