13636-53-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3,4-Dimethylphenylhydrazine hydrochloride is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Scientific Research:
3,4-Dimethylphenylhydrazine hydrochloride is used as a model compound in scientific research for studying the toxic effects of hydrazine compounds on biological systems, aiding in the understanding of their mechanisms of action and potential health hazards.

Upstream product

• 95-64-7 4-amino-o-xylene 
• 69457-08-5 3,4-dimethyl-benzenediazonium; chloride 

Downstream Products

• 374924-86-4 5-tert-butyl-2-(3,4-dimethylphenyl)-2,4-dihydropyrazol-3-onene 
• 1025893-78-0 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine 
• 781663-71-6 ethyl 1-(3,4-dimethylphenyl)-5-phenyl-1H-pyrazole-3-carboxylate 
• 277299-73-7 1-(3,4-Dimethylphenyl)-1H,4H-pyrazolin-3,5-dione 
• 374924-95-5 1-(3,4-dimethylphenyl)-2-ethoxy-3-pyrazolin-5-one 
• 277299-70-4 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 277299-76-0 3-tert-butyl-1-(3,4-dimethylphenyl)-3-pyrazolin-5-one 
• 863185-93-7 1-(3,4-dimethylphenyl)-3-phenyl-5-(4-methoxyphenyl)-2-pyrazoline 
• 1335240-38-4 1-(3,4-dimethylphenyl)-3-phenyl-5-(4-ethoxyphenyl)-2-pyrazoline 
• 1335240-40-8 1-(3,4-dimethylphenyl)-3-phenyl-5-(4-propyloxyphenyl)-2-pyrazoline 
• 1335240-42-0 1-(3,4-dimethylphenyl)-3-phenyl-5-(4-butyloxyphenyl)-2-pyrazoline 
• 1418202-43-3 2-(3,4-dimethylphenyl)-1,2-dihydrophthalazine 

Relevant academic research and scientific papers

Synthesis of new 1-(3,4-dimethylphenyl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one derivatives

New substituted pyrazolo[3,4-d]pyrimidin-4-ones have been synthesized as a result of a series of transformations including hydrolysis of ethyl 5-amino-1H-pyrazole-4-carboxylates, cyclization of the carboxylic acids thus obtained to pyrazolo[3,4-d][1,3]oxazin-4(1H)-ones, and treatment of the latter with substituted anilines. The final pyrazolo[3,4-d]pyrimidin-4-one derivatives can also be synthesized from 5-(arylamido)-1H-pyrazole-4-carboxylic acids in the presence of a catalytic amount of anhydrous zinc(II) chloride.

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.