1025893-78-0

Basic information

• Product Name: 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine
• Synonyms: 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine
• CAS NO: 1025893-78-0
• Molecular Weight: 243.352
• Mol File: 1025893-78-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine(1025893-78-0)
• EPA Substance Registry System: 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine(1025893-78-0)

Safety Data

• Hazardous Substances Data: 1025893-78-0(Hazardous Substances Data)

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 60481-51-8 3,4-dimethylphenylhydrazine hydrochloride 
• 13636-53-8 3,4-dimethylphenylhydrazine 

Relevant articles and documents

Scale-up of microwave-assisted reactions in a multimode bench-top reactor

An evaluation of a new bench-top microwave batch reactor that uses a single 1 L reaction vessel is presented. Several microwave-assisted organic reactions have been scaled-up, including Newman Kwart and Diels-Alder reactions, Pd-catalyzed cross-couplings, heterocycle synthesis, aromatic substitution, and a Knoevenagel condensation. A range of different solvents (high and low microwave absorbing), varying reaction times (4 s up to 2 h), and temperatures (120-250 °C) have been explored in these investigations. For all studied transformations, it was possible to perform a direct scale-up (up to 720 mL reaction volume) without changing the previously optimized reaction conditions achieved in a laboratory-scale single-mode microwave instrument (2-20 mL processing volume), obtaining similar isolated product yields. A scalability up to 360-fold, when moving from 3 mmol up to 1.08 mol, was demonstrated, and isolated product yields up to 300 g (2.5 mol scale) in a single run could be accomplished, providing the potential for a kilogram output per day for specific transformations by performing multiple sequential runs.

Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists

A series of 1-indazol-3-(1-phenylpyrazol-5-yl)methyl ureas were investigated as hTRPV1 antagonists. The structure–activity relationship study was conducted systematically for both the indazole A-region and the 3-trifluoromethyl/t-butyl pyrazole C-region to optimize the antagonism toward the activation by capsaicin. Among them, the antagonists 26, 50 and 51 displayed highly potent antagonism with Ki(CAP) = 0.4–0.5 nM. Further, in vivo studies in mice indicated that these derivatives both antagonized capsaicin induced hypothermia, consistent with their in vitro activity, and themselves did not induce hyperthermia. In the formalin model, 51 showed anti-nociceptive activity in a dose-dependent manner.

KINASE INHIBITORS

Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract