136386-75-9Relevant academic research and scientific papers
Total Synthesis and Structural Reassignment of (±)-Cereoanhydride
Ren, Zhiqiang,Hao, Yu,Hu, Xiangdong
supporting information, p. 4958 - 4961 (2016/10/18)
The first total synthesis of (±)-cereoanhydride has been achieved under the inspiration of its biosynthetic hypothesis. The tricyclic skeleton of trypethelone, the proposed biosynthetic precursor of cereoanhydride, was constructed by an interesting ring e
NOVEL CYTOCHROME P450 INHIBITORS AND THEIR METHOD OF USE
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Paragraph 0447; 0448, (2016/10/08)
Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndro
ANALGESIC COMPOUNDS, METHODS, AND FORMULATIONS
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Paragraph 0050, (2013/09/12)
Provided are analgesic compounds, and salts thereof, of formula: (I) wherein A is: (A) Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.
ANALGESIC COMPOUNDS, METHODS, AND FORMULATIONS
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Page/Page column 16-17, (2012/08/08)
Provided are compounds, and salts thereof, of formula (I): wherein (A) is R1 is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C5 alkanol, -(C1-C5 alkyl)phenyl, or phenyl, or a group of the formula -C(O)-R12, where R12 may be C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C5 alkanol, -(C1-C5 alkyl)phenyl, or phenyl; R2 and R3 are independently hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, C1-C5 haloalkyl, or C1-C5 haloalkoxy; R4 and R5 are independently hydrogen, C1-C5 alkyl, or -(C1-C5 alkyl)phenyl; R6 is hydrogen, hydroxy, or is absent; R7 is hydrogen; R8 and R9 are independently hydrogen or methyl; R10 is hydrogen; R11 is hydrogen or C1-C5 alkyl; or R7 and R10 combine to form -CH2- or -(CH2)2-; or R8 and R9 combine to form a cyclopropyl group with the carbon to which they are attached; or R10 and R11 combine to form -CH2- or -(CH2)3-. Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.
ANALGESIC COMPOUNDS, METHODS, AND FORMULATIONS
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Page/Page column 16-17, (2012/08/08)
Provided are analgesic compounds, and salts thereof, of formula: ( I ) wherein A is: ( A ) Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.
Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure
Roush, William R.,Neitz, R. Jeffrey
, p. 4906 - 4912 (2007/10/03)
The originally proposed structure (2) of landomycinone, the aglycone of landomycin A, has been synthesized and shown to be nonidentical to the naturally derived landomycin A aglycone. The synthesis of 2 features the Doetz benzannulation reaction of chromium carbene 5 and alkyne 6, and the intramolecular Michael-type cyclization reaction of the phenolic naphthoquinone 20. It is proposed that natural landomycinone possesses the alternative structure 3, but attempts to access this structure via the Michael-type cyclization of the isomeric phenolic naphthoquinone 38 have been unsuccessful.
The Synthesis Of Substituted Aryl Diazirines. A Bifunctional Reagent Suitable For Application To Photoaffinity Labelling Studies.
Baldwin, Jack E.,Jesudason, Cynthia D.,Moloney, Mark G.,Morgan, D. Rhys,Pratt, Andrew J.
, p. 5603 - 5614 (2007/10/02)
The 1,3,5-trisubstituted aryl diazirine (2) has been synthesised as a photoaffinity probe and has been elaborated to a reagent suitable for application to studies of penicillin and cephalosporin biosynthetic enzymes.Keywords: photoaffinity; diazirine; bif
