136494-83-2Relevant academic research and scientific papers
Enantioselective Copper-Catalyzed Radical Ring-Opening Cyanation of Cyclopropanols and Cyclopropanone Acetals
Chen, Pinghong,Guo, Yin-Long,Liu, Guosheng,Wang, Lei,Wu, Lianqian
supporting information, p. 2189 - 2194 (2020/04/17)
A novel approach for enantioselective cyanation of cyclopropanols and their derivatives through copper-catalyzed radical relay processes has been developed. Various cyclopropanols and cyclopropanone acetals are compatible to the catalytic conditions, providing β-carbonyl nitriles with excellent enantioselectivity. These products can be readily converted to chiral γ-amino acids derivatives and drugs such as (R)-baclofen. Preliminary mechanistic studies have supported a ring-opening process for cyclopropanoxy radicals followed by copper-catalyzed enantioselective cyanation of benzylic radicals to form the C?CN bonds in an enantioselective manner. (Figure presented.).
Diastereoselective synthesis of cis-1,2-disubstituted cyclopropanols and cyclopent-3-enols via SmI2 mediated C-N(Bt) bond cleavage
Xie, Tingting,Zhou, Liejin,Shen, Mengmeng,Li, Jianyong,Lv, Xin,Wang, Xiaoxia
, p. 3982 - 3987 (2015/06/08)
Abstract Diastereoselective synthesis of cis-1,2-disubstituted cyclopropanols and cyclopent-3-enols has been achieved from readily available β-benzotriazolyl ketones (β-Bt ketones) via a C-N(Bt) bond cleavage/cyclization process promoted by SmI2/sub
Electrochemically Promoted Cyclocoupling of 1,3-Dienes or Styrenes with Aliphatic Carboxylic Esters
Shono, Tatsuya,Ishifune, Manabu,Kinugasa, Hiroshi,Kashimura, Shigenori
, p. 5561 - 5563 (2007/10/02)
The cathodic cyclocoupling of 1,3-dienes 1 with aliphatic esters 2 is promoted by a magnesium electrode and yields homologs of 3-cyclopentenol.Under similar reaction conditions, the coupling of styrenes with 2 affords 2-phenylcyclopropanol derivatives, an
