136496-85-0Relevant academic research and scientific papers
Synthesis of novel functionalized gem-bisphosphonates
Sturtz,Guervenou
, p. 661 - 662 (1991)
Michael-type addition of carbanions to tetraethyl ethylidenebisphosphonate affords functionalized gem-bisphosphonates, which are potentially useful in the therapy of bone tissues.
Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters
Schlachter, Stephen T.,Galinet, Louise A.,Shields, Sharon K.,Aspar, Danielle G.,Dunn, Colin J.,Staite, Nigel D.,Nugent, Richard A.
, p. 1093 - 1096 (2007/10/03)
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti-inflammatory effects.
Bisphosphonic acid derivatives as anti-arthritic agents
-
, (2008/06/13)
The bisphosphonates of formula (III) bicyclic bisphosphonates (V), and cyclic bisphosphonates (VII) are useful as anti-arthritic agents and do not have the side effects of anti-arthritic agents which are prostaglandin synthetase inhibitors.
