1365284-12-3Relevant academic research and scientific papers
A palladium-catalyzed enantioselective addition of arylboronic acids to cyclic ketimines
Yang, Guoqiang,Zhang, Wanbin
, p. 7540 - 7544 (2013)
Sly as Nicox: A palladium-catalyzed addition of arylboronic acids to ketimines has been developed to efficiently provide products in up to 99 % yield and 96 % ee. The reactions could be run under aerobic conditions and with unpurified trifluoroethanol (TFE). A pyrrolidine compound bearing a chiral α-tertiary amine was synthesized in several steps without loss of enantioselectivity. TFA=trifluoroacetate. Copyright
Simple branched sulfur-olefins as chiral ligands for Rh-catalyzed asymmetric arylation of cyclic ketimines: Highly enantioselective construction of tetrasubstituted carbon stereocenters
Wang, Hui,Jiang, Tao,Xu, Ming-Hua
supporting information, p. 971 - 974 (2013/04/10)
New, simple, sulfinamide-based branched olefin ligands have been developed and successfully used in Rh-catalyzed asymmetric arylations of cyclic ketimines, providing efficient and highly enantioselective access to valuable benzosultams and benzosulfamidat
Asymmetric synthesis of (Triaryl)methylamines by rhodium-catalyzed addition of arylboroxines to cyclic N-sulfonyl ketimines
Nishimura, Takahiro,Noishiki, Akira,Chit Tsui, Gavin,Hayashi, Tamio
, p. 5056 - 5059 (2012/05/05)
Asymmetric addition of arylboroxines to cyclic N-sulfonyl ketimines proceeded in the presence of a rhodium catalyst coordinated with a chiral diene ligand to give high yields of benzosultams, where a triaryl-substituted stereogenic carbon center was created with high enantioselectivity (93-99% ee). The chiral benzosultams were transformed into the chiral (triaryl)methylamines by breaking the cyclic structure.
