1365284-58-7

Basic information

• Product Name: Fmoc-Sec(Mob)-OMe
• Synonyms: Fmoc-Sec(Mob)-OMe
• CAS NO: 1365284-58-7
• Molecular Weight: 524.475
• Mol File: 1365284-58-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Fmoc-Sec(Mob)-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Sec(Mob)-OMe(1365284-58-7)
• EPA Substance Registry System: Fmoc-Sec(Mob)-OMe(1365284-58-7)

Safety Data

• Hazardous Substances Data: 1365284-58-7(Hazardous Substances Data)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 62212-22-0 1,2-bis(4-methoxybenzyl)diselane 
• 156017-42-4 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-iodo-propionic acid methyl ester 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 82911-78-2 N-[(9-fluorenylmethoxy)carbonyl]-L-serine methyl ester 
• 229962-91-8 methyl (2S)-2-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-3-(((4-methylbenzene)sulfonyl)oxy)propanoate 

Downstream Products

• 150308-80-8 N-(9-fluorenylmethoxycarbonyl)-Se-(p-methoxyphenylmethyl)-L-selenocysteine 

Relevant articles and documents

Improved synthetic routes to the selenocysteine derivatives useful for Boc-based peptide synthesis with benzylic protection on the selenium atom

Selenocysteine (Sec) derivatives, i.e., Boc-Sec(MBn)-OH (1) and Boc-Sec(MPM)-OH (2), which are useful for chemical synthesis of selenopeptides, were obtained from L-serine in five steps with total yields of 73% and 74%, respectively. The enantiomeric excesses were confirmed to be >99% e.e. by optical resolution using a chiral column on HPLC. On the other hand, for the case of a Fmoc-protected Sec derivative, i.e., Fmoc-Sec(MPM)-OH, similar reactions resulted in low yields and partial racemization taking place. [PRESENTED EQUATION]