1365321-45-4Relevant academic research and scientific papers
Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5- trifluorophenyl)butanoic acid: A synthon for sitagliptin and its derivatives
Fistikci, Meryem,Gundogdu, Ozlem,Aktas, Derya,Secen, Hasan,Sahin, M. Fethi,Altundas, Ramazan,Kara, Yunus
, p. 2607 - 2610 (2012/05/20)
A new synthetic strategy for (R)- and (S)-3-hydroxy-4-(2,4,5- trifluorophenyl)butanoic acid, a building block in the preparation of sitagliptin and its derivatives, was developed. Pd(OAc)2 catalyzed coupling of 2,4,5-trifluoro-1-iodobenzene wit
