13656-59-2

Basic information

• Product Name: 2,4-difluoro-N-phenylbenzenesulfonamide
• CAS NO: 13656-59-2
• Molecular Weight: 269.272
• Mol File: 13656-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-difluoro-N-phenylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-N-phenylbenzenesulfonamide(13656-59-2)
• EPA Substance Registry System: 2,4-difluoro-N-phenylbenzenesulfonamide(13656-59-2)

Safety Data

• Hazardous Substances Data: 13656-59-2(Hazardous Substances Data)

Upstream product

• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 62-53-3 aniline 
• 3782-65-8 2,4-Difluorobenzene sulfonyl fluoride 
• 26120-88-7 2,4-dichlorobenzenesulfonyl fluoride 

Relevant articles and documents

Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened a commercial library and identified the hit compound 1 bearing a benzenesulfonamide quinoline scaffold that inhibited Rev activity and HIV-1 infectivity. Compounds bearing this scaffold were synthesized and their SAR was studied. We identified compound 20 with low toxicity and potent activity to inhibit HIV-1 replication by affecting Rev function.