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Benzenesulfonyl fluoride, 2,4-difluoro-, also known as 2,4-difluorobenzenesulfonyl fluoride or DFBSF, is a chemical compound with the molecular formula C6H3F2O2S. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. DFBSF is a potent and selective inhibitor of serine proteases, a class of enzymes that play a crucial role in various biological processes, including blood clotting, digestion, and immune response. Due to its ability to irreversibly inhibit serine proteases, DFBSF is widely used in biochemical research and as a reagent in the study of protease activity. It is also employed in the synthesis of various pharmaceuticals and agrochemicals. However, it is important to note that DFBSF is a hazardous substance and should be handled with care due to its potential toxicity and irritant properties.

3782-65-8

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3782-65-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3782-65-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,8 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3782-65:
(6*3)+(5*7)+(4*8)+(3*2)+(2*6)+(1*5)=108
108 % 10 = 8
So 3782-65-8 is a valid CAS Registry Number.

3782-65-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Difluorobenzene sulfonyl fluoride

1.2 Other means of identification

Product number -
Other names 2,4-Difluor-benzolsulfofluorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3782-65-8 SDS

3782-65-8Relevant academic research and scientific papers

Visible-Light-Mediated Synthesis of Sulfonyl Fluorides from Arylazo Sulfones

Bui, Tien Tan,Tran, Van Hieu,Kim, Hee-Kwon

, p. 341 - 347 (2021/10/14)

Sulfonyl fluorides are useful motifs for a wide range of applications in organic synthesis including sulfur (VI) fluoride exchange-based “click chemistry.” Herein, a visible-light-mediated synthesis of sulfonyl fluorides from arylazo sulfones is described. In the present study, K2S2O5 and N-fluorobenzenesulfonimide (NFSI) were used as the sulfonyl source and fluorinating agent, respectively, for visible-light-mediated fluorosulfonylation of arylazo sulfones to prepare various sulfonyl fluorides in 60–85% yield. This protocol is a synthetic approach to provide useful sulfonyl fluoride structures at room temperature. (Figure presented.).

Sulfonyl chloride as a disposable electron withdrawing substituent in halex fluorinations

Kageyama, Hiroyuki,Suzuki, Hiroshi,Kimura, Yoshikazu

, p. 85 - 89 (2007/10/03)

Syntheses of 1,3-difluorobenzene and 2,6-difluorotoluene are described via chlorosulfonation, catalytic Halex-fluorination, and desulfination of 1,3-dichlorobenzene and 2,6-dichlorotoluene.

Tetraphenylphosphonium bromide-catalyzed 'Halex' fluorination of chloroaryl sulfonyl chlorides

Suzuki, Hiroshi,Kageyama, Hiroyuki,Yoshida, Yasuo,Kimura, Yoshikazu

, p. 335 - 337 (2007/10/02)

Halogen-exchange of chloroaryl sulfonylchloride derivatives with spray-dried potassium fluoride was found to proceed efficiently by employing tetraphenylphosphonium bromide as a catalyst.Subsequent desulfonylation of the fluoroaryl sulfonyl derivatives readily afforded fluoroaromatics under acidic condition.

Preparation of fluorobenzenesulfonyl fluorides by exchange fluorination

-

, (2008/06/13)

Fluorobenzenesulfonyl fluorides are prepared by chlorine/fluorine exchange fluorinating a chlorobenzenesulfonyl fluoride with an alkali metal fluoride, in a aprotic polar solvent and at a temperature ranging from about 100° C. to about 240° C.

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