1365634-50-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorothioyl)amino)propanoate is used as a potential therapeutic agent for various medical conditions due to its complex structure and the presence of multiple functional groups that can interact with biological targets.
Used in Materials Science:
In the field of materials science, (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorothioyl)amino)propanoate may be utilized in the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity, owing to its unique molecular architecture.
Used in Chemical Research:
(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorothioyl)amino)propanoate can also be employed as a research tool in chemical laboratories for studying the effects of its various functional groups on chemical reactivity, selectivity, and the development of new synthetic methods or reactions.

Upstream product

• 1365255-67-9 (O-phenyl-N-(S)-1-(isopropoxycarbonyl)eth-1-yl)thiophosphoramidic chloride 
• 31448-54-1 2'-C-methyluridine 
• 18961-96-1 O-phenylphosphorodichloridothioate 
• 108-95-2 phenol 
• 1365634-48-5 2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate 
• 1365634-47-4 2'-methyluridine 
• 1365634-46-3 2'-methyluridine 

Relevant academic research and scientific papers

METHODS OF STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED NUCLEOSIDE ANALOGS

The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

DEUTERATED NUCLEOSIDE PRODRUGS USEFUL FOR TREATING HCV

Deuterated nucleoside analogs of Formula (I) and the pharmaceutically acceptable salts thereof are provided by this disclosure The variables, e.g., B1, Y, R1, R2, R3, R3′, R4, R5, R6, R7, R8, and R9 carry definitions set forth in the disclosure. Compounds of Formula (I) are deuterated at one or more positions and the deuterium enrichment at each deuterated positions is at least 50%. Compounds and salts of Formula (I) are useful for treating viral infections, including HCV infections.

METHODS OF PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS

Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.

SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG

The present application relates to solid state forms, for example, crystalline forms of 2'- C-methyluridine-5 '-(O-phenyl-N-(S)- 1 -(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2'-C

SUBSTITUTED NUCLEOTIDE ANALOGS

Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate