1365656-14-9Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of some 3, 5-diaryl-2-pyrazoline derivatives
Khalil, Omneya M.,Refaat, Hanan M.
, p. 1581 - 1590 (2012/06/16)
Eleven new 3-(4-bromophenyl)-5-(4-flirorophenyl)-2-pyrazoline derivatives 4-9 and 11-15 were synthesized by using 1-(4-bromophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (3). The newly synthesized compounds were evaluated for anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compound of this series, 7 was found to be most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.
