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2-Propen-1-one, 1-(4-bromophenyl)-3-(4-fluorophenyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

98991-32-3

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98991-32-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 98991-32-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,9,9 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98991-32:
(7*9)+(6*8)+(5*9)+(4*9)+(3*1)+(2*3)+(1*2)=203
203 % 10 = 3
So 98991-32-3 is a valid CAS Registry Number.

98991-32-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-bromophenyl)-3-(4-fluorophenyl)prop-2-en-1-one

1.2 Other means of identification

Product number -
Other names 2-Propen-1-one,1-(4-bromophenyl)-3-(4-fluorophenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98991-32-3 SDS

98991-32-3Relevant articles and documents

Efficient base-free asymmetric one-pot synthesis of spiro[indoline-3,3′-pyrrolizin]-2-one derivatives catalyzed by chiral organocatalyst

Chithiraikumar, Chinnadurai,Ponmuthu, Kottala Vijaya,Harikrishnan, Muniyasamy,Malini, Nelson,Sepperumal, Murugesan,Siva, Ayyanar

, p. 895 - 909 (2020/10/29)

A 1,3-dipolar cycloaddition reaction has been performed under organocatalytic conditions with high enantioselectivity by the utilization of bipyridine-based chiral quaternary ammonium bromide as an organocatalyst. Here, the reaction of 1,3-dipolar cycloaddition of azomethine ylide generated in situ from the decarboxylative condensation of α-amino acids and non-enolizable 1,2-diketones to the above dipolarophiles takes place.

Synthesis, characterization, in vitro cholinesterase and hRBCs hemolysis assay and computational evaluation of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonates

Shaikh, Sarfaraz,Dhavan, Pratik,Uparkar, Jasmin,Singh, Pinky,Vaidya,Jadhav,Ramana

, (2021/10/12)

A series of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonate derivatives were synthesized by subjecting 2,3-dihydrobenzothiazepine to Pudovik reaction using diethyl phosphite. Tested derivatives exhibited better AChE inhibition (0.86–12

Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts

Huang, Wenhua,Xue, Jing-Yu

, (2021/11/08)

Alkaline hydrolysis of a variety of (4-(2-alkenoyl)phenyl)triarylphosphonium bromides is reported. This hydrolysis triggers coupling of 4-(2-alkenoyl)phenyl with one aryl via phosphorus(V). Both diarylphosphinite and an α,β-unsaturated ketone are in situ generated and then undergo phospha-Michael addition to provide β-diarylphosphoryl ketones bearing a biaryl moiety in 27–70% yields in the absence of a transition metal.

Design, synthesis, and biological evaluation of novel thienopyrimidine derivatives as PI3Kα inhibitors

Yu, Lide,Wang, Qinqin,Wang, Caolin,Zhang, Binliang,Yang, Zunhua,Fang, Yuanying,Zhu, Wufu,Zheng, Pengwu

, (2019/10/02)

Three series of novel thienopyrimidine derivatives 9a-l, 15a-l, and 18a-h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicity against the tested cancer cell lines. The most promising compound 9a showed moderate activity with IC50 values of 12.32 ± 0.96, 11.30 ± 1.19, 14.69 ± 1.32, and 9.80 ± 0.93 μM, respectively. The inhibitory activities of compounds 9a and 15a against PI3Kα and mTOR kinase were further evaluated. Compound 9a exhibited PI3Kα kinase inhibitory activity with IC50 of 9.47 ± 0.63 μM. In addition, docking studies of compounds 9a and 15a were also investigated.

Synthesis and bioevaluation of thienopyrimidines bearing a pyrazoline unit as selective PI3Kα inhibitors

Lai, Luogen,Wang, Qinqin,Zhang, Binliang,Xiao, Zhen,Yang, Zunhua,Yang, Qi,Luo, Zixin,Zhu, Wufu,Xu, Shan

, p. 29579 - 29589 (2019/10/01)

A series of thienopyrimidines containing a pyrazoline unit (4a-d, 7a-d and 13a-l) were designed and synthesized. The target compounds were evaluated for antiproliferative activity against A549, HepG2 and MCF-7 cancer cell lines. Among the twenty target compounds, most of them exhibited excellent antiproliferative activity against one or several cancer cell lines. Compound 13f showed the best activity against A549, MCF-7 and HepG2 cancer cell lines, with IC50 values of 2.84 ± 0.09 μM, 2.88 ± 0.43 μM and 2.08 ± 0.36 μM, respectively. Four selected compounds (13c, 13f, 13g and 13h) were further evaluated for their inhibitory activity against the PI3Kα/mTOR protein kinase. Moreover, time-dependent and dose-dependent experiments, AO fluorescence staining, Annexin V-FITC/PI staining and docking studies were carried out in this study. The results indicated that compound 13f may be a potential selective PI3Kα inhibitor.

Synthesis and biological evaluation of fluoropyrazolesulfonylurea and thiourea derivatives as possible antidiabetic agents

Faidallah, Hassan M.,Al-Mohammadi, Manal M.,Alamry, Khalid A.,Khan, Khalid A.

, p. 157 - 163 (2016/12/03)

Fluorinated pyrazoles, benzenesulfonylurea and thiourea and their cyclic sulfonylthiourea derivatives were prepared as hypoglycemic agents. The chemistry involves the condensation of 4-hydrazino benzenesulfonamide hydrochloride with fluorochalcones to giv

CsOH/γ-Al2O3: A heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines

Nimkar, Amey,Ramana,Betkar, Rahul,Ranade, Prasanna,Mundhe, Balaji

, p. 2541 - 2546 (2016/03/22)

A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/γ-Al2O3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reac

Novel benzothiazole based sulfonylureas/sulfonylthioureas: Design, synthesis and evaluation of their antidiabetic potential

Kharbanda, Chetna,Alam, Mohammad Sarwar,Hamid, Hinna,Javed, Kalim,Bano, Sameena,Ali, Yakub,Dhulap, Abhijeet,Alam, Parwez,Pasha

, p. 6777 - 6786 (2016/08/10)

In the present study, twenty-eight benzothiazole based sulfonylureas/sulfonylthioureas were synthesized and were assessed for their antidiabetic effect in a normoglycemic rat model by the in vivo oral glucose tolerance test (OGTT). All the synthesized com

Synthesis and evaluation of pyrazolines bearing benzothiazole as anti-inflammatory agents

Kharbanda, Chetna,Alam, Mohammad Sarwar,Hamid, Hinna,Javed, Kalim,Bano, Sameena,Dhulap, Abhijeet,Ali, Yakub,Nazreen, Syed,Haider, Saqlain

, p. 5804 - 5812 (2015/02/02)

The present study aims at the synthesis of pyrazolines bearing benzothiazole and their evaluation as anti-inflammatory agents. The synthesized compounds were evaluated for their anti-inflammatory potential using carrageenan induced paw edema model. Two co

MW assisted synthesis of some pyrazoles containing benzotriazole moiety: An environmentally benign approach

Tiwari, Urvashi,Ameta, Chetna,Rawal, Manish K.,Ameta, Rakshit,Punjabi, Pinki B.

, p. 432 - 439 (2013/05/08)

MW assisted synthesis of pyrazoles containing benzotriazole moieties 4a-n has been achieved by cyclocondensation of substituted chalcones 3a-n with hydrazide of benzotriazole 2 in presence of glacial acetic acid (GAA). Thus, synthesized compounds 4a-n have been characterized by their spectral data and evaluated for their antibacterial and antifungal activities against various microbes.

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