1365699-34-8

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 155252-35-0 4β-amino-4-deoxypodophyllotoxin 
• 1365699-32-6 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-nitrobenzamide 

Downstream Products

• 1365699-43-9 4β-[4'-(5-bromothiophene-2-sulfonamido)benzamide]podophyllotoxin 
• 1365699-49-5 4β-[4'-(quinoline-8-sulfonamido)benzamide]podophyllotoxin 
• 1365699-47-3 4β-[4'-(napthalene-1-sulfonamido)benzamide]podophyllotoxin 
• 1365699-51-9 4β-[4'-(biphenyl-4-sulfonamido)benzamide]podophyllotoxin 
• 1365699-53-1 4β-[4'-(4-phenoxyphenylsulfonamido)benzamide]podophyllotoxin 
• 1365699-55-3 4β-[4'-(4-methoxyphenylsulfonamido)benzamide]podophyllotoxin 
• 1365699-45-1 4β-[4'-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)benzamide]podophyllotoxin 
• 1449741-70-1 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-furylmethyl)amino)carbonyl)amino)benzamide 
• 1449741-68-7 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-(((4-methoxyanilino)carbonyl)amino)benzamide 
• 1449741-65-4 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-(((3-chloro-4-fluoroanilino)carbonyl)amino)benzamide 
• 1449741-72-3 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide 
• 1449741-71-2 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-chloroethyl)amino)carbonyl)amino)benzamide 
• 1449741-69-8 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-(((1-naphthylamino)carbonyl)amino)benzamide 
• 1449741-67-6 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-(((3,5-di(trifluoromethyl)anilino)carbonyl)amino)benzamide 

Relevant academic research and scientific papers

4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase i and IIα inhibitors and apoptosis inducing agents

A series of 4β-[4′-(1-(aryl)ureido)benzamide]podophyllotoxin congeners (11a-l) were synthesized and evaluated for their cytotoxic activity against six human cancer cell lines. Some of the compounds like 11a, 11h, 11k and 11l showed significant anti-prolif

Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4′-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents

A series of new 4β-sulphonamido and 4β-[(4′-sulphonamido) benzamide] conjugates of podophyllotoxin (11a-j and 15a-g) were synthesized and evaluated for anticancer activity against six human cancer cell lines and found to be more potent than etoposide. Som