1366067-59-5

Usage

Uses

Used in Pharmaceutical Industry:
JWH 387 is used as an analgesic agent for its potent agonist activity at CB1 and CB2 receptors, providing pain relief and potentially offering an alternative to traditional pain management treatments.
Used in Research and Development:
JWH 387 is used as a research compound for studying the effects and mechanisms of action of cannabinoids on the CB1 and CB2 receptors, which can contribute to the development of new therapeutic strategies and understanding of the endocannabinoid system.

Upstream product

• 16650-55-8 4-bromonaphthalene-1-carboxylic acid 
• 35615-97-5 4-bromo-naphthalene-1-carboxylic acid methyl ester 
• 87700-65-0 4-bromo-1-naphthoic acid chloride 
• 46258-62-2 1-(4-bromonaphthalen-1-yl)ethanone 
• 90-11-9 1-Bromonaphthalene 
• 110-53-2 1-Bromopentane 
• 1366068-34-9 3-(4-bromo-1-naphthoyl)indole 
• 59529-21-4 1-pentyl-1H-indole 

Relevant academic research and scientific papers

Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents

To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.