46258-62-2

Usage

Uses

Used in Organic Synthesis:
1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is used as a building block for the creation of more complex molecules, facilitating the synthesis of a wide range of organic compounds.
Used in Chemical Research:
In the field of chemical research, 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is utilized to study and understand the chemical properties and reactivity of ketone derivatives, which is essential for the advancement of chemical science.
Used in Pharmaceutical Industry:
1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is used as a key intermediate in the development of new pharmaceutical compounds, potentially leading to the discovery of novel drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is employed as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides, contributing to the development of more effective and environmentally friendly products.
Used in Materials Science:
1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is utilized in materials science for the development of new materials with unique properties, such as high thermal stability, electrical conductivity, or optical characteristics, which can be applied in various industries.

InChI:InChI=1/C12H9BrO/c1-8(14)9-6-7-12(13)11-5-3-2-4-10(9)11/h2-7H,1H3

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 83-53-4 1,4-dibromonaphthalene 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 58149-70-5 1-(4-Bromo-α-naphthyl)ethyl alcohol 

Downstream Products

• 16650-55-8 4-bromonaphthalene-1-carboxylic acid 
• 32405-50-8 1,1-bis(pyridinium)methane diiodide 
• 374926-06-4 2-(4-bromonaphthalene-1-carbonyl)acetonitrile 
• 1312609-63-4 C₂₀H₁₆O₂ 
• 1366067-59-5 (4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone 
• 1366067-63-1 JWH-394 
• 87700-65-0 4-bromo-1-naphthoic acid chloride 
• 1853997-27-9 2-(1-bromonaphthalen-4-yl)-1,10-phenanthroline 

Relevant academic research and scientific papers

Dearomative Allylation of Naphthyl Cyanohydrins by Palladium Catalysis: Catalyst-Enhanced Site Selectivity

A dearomative allylation of naphthyl cyanohydrins with allyl borates and allyl stannanes under palladium catalysis was developed. At the initial stage of this study, the dearomative reaction (C4 substitution of the aromatics) was competing with benzyl substitution. To circumvent this issue, the use of palladium and meta-disubstituted triarylphosphine as the catalyst in a 1:1 ratio was found to enhance the site selectivity, furnishing the desired dearomatized products. Further derivatizations of products were also successful.

Preparation method of 1,4-naphthalic acid

The invention relates to a preparation method of 1,4-naphthalic acid, which is characterized by comprising the steps of performing Friedel-Crafts reaction on 1-naphthalene bromide serving as an initial raw material and acetyl chloride to generate 4-bromo-1-acetyl naphthalene; then carrying out oxidation by using pypocholoride to obtain 4-bromo-1-naphthoic acid; reacting 4-bromine-1-naphthoic acid with cuprous cyanide in a polar aprotic solvent in the presence of potassium iodide and copper sulfate in catalytic doses to generate a 4-cyano naphthoic acid copper salt complex; and carrying out alkaline hydrolysis on the 4-cyano naphthoic acid copper salt complex to obtain the 1,4-naphthalic acid. According to the preparation method of the naphthalene-1,4-dicarboxylic acid, the raw materials are easy to obtain, and the product does not contain color impurities, is high in purity and good in quality, and can be directly used as an intermediate of a dye, an ultraviolet light absorber, a scintillator and an optical whitening agent for further synthesis.

Concise Synthesis of Polysubstituted Carbohelicenes by a C?H Activation/Radical Reaction/C?H Activation Sequence

Disclosed herein is the merging of C?H activation and radical chemistry, enabling rapid access to a structurally diverse family of fused carbohelicenes through the fusion of α-acetylnaphthalenes with alkynes under oxidative conditions. This cascade process exhibits exquisite chemoselectivity and regioselectivity. The reaction pathway was analyzed by intermediate separations, control experiments, radical trapping, EPR, MALDI-TOF-MS, and ESI-HRMS experiments, and shown to involve a C2?H activation/radical reaction/C8?H activation relay.

Cu(II)-Catalyzed Ligand-Free Oxidation of Diarylmethanes and Second Alcohols in Water

We developed a simple and efficient Cu(II)-catalyzed ligand-free oxidation of diarylmethanes and secondary alcohols using 70% tert-butyl hydroperoxide (TBHP) in water. A series of diarylmethanes were directly oxidized into diaryl ketones in 67%–98% yields. Additionally, various secondary alcohols were also transformed into the desired products in 48%–98% yields. Importantly, the catalytic system in the absence of any organic solvent, surfactant, or phase transfer agent, had a wide substrate scope and a high tolerance for various functional groups.

Metal-free oxidation of secondary benzylic alcohols using aqueous TBHP

We report a simple, yet efficient metal-free oxidation of secondary benzylic alcohols in the presence of t-butyl hydroperoxide (70% TBHP) with high yields of up to 98%. This type of reaction can be carried out using a wide variety of substrates, requires no other organic solvent, and proves to be tolerant toward a variety of different functional groups.

Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents

To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.

HEPATITIS C VIRUS INHIBITORS

The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment o

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

KINASE INHIBITORS

The invention provides the use of a compound or a composition comprising said compound for inhibiting the activity of at least one kinase, other than ROCK kinase, in vitro or in vivo, pharmaceutical and/or veterinary compositions comprising such compounds, medical and veterinary uses of such compounds and the compounds themselves.

Synthesis of vinyl-substituted β-diketones for polymerizable metal complexes

Polymerizable β-diketones for application to metal ion coordination have been prepared and characterized. Bromine-substituted β-diketones were synthesized under Claisen-Schmidt-type condensation conditions. Vinyl groups were substituted for the halide by