46258-62-2

Basic information

• Product Name: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE
• Synonyms: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE;1-(4-Bromonaphthalen-1-yl)ethanone;1-Acetyl-4-bromonaphthalene;4'-Bromo-1'-acetonaphthone;4-Bromo-1-acetonaphthone;4-broMo-1-acetylnaphthalene;1-(4-bromononaphthalen-4-yl)ethanone
• CAS NO: 46258-62-2
• Molecular Formula: C₁₂H₉BrO
• Molecular Weight: 249.10326
• Mol File: 46258-62-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 50-51℃
• Boiling Point: 370℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.454
• Vapor Pressure: 1.12E-05mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE(46258-62-2)
• EPA Substance Registry System: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE(46258-62-2)

Safety Data

• Hazardous Substances Data: 46258-62-2(Hazardous Substances Data)

Usage

General Description

1-(1-Bromonaphthalen-4-yl)ethanone is a chemical compound with the molecular formula C12H9BrO. It is a ketone derivative containing a naphthalene ring substituted with a bromine atom at the 1-position and an ethanone group. 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE is used in organic synthesis and chemical research as a building block for the creation of more complex molecules. It has potential applications in the pharmaceutical and agrochemical industries, as well as in materials science. The chemical properties and reactivity of 1-(1-Bromonaphthalen-4-yl)ethanone make it a valuable tool in the development of new compounds and technologies.

InChI:InChI=1/C12H9BrO/c1-8(14)9-6-7-12(13)11-5-3-2-4-10(9)11/h2-7H,1H3

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 75-36-5 acetyl chloride 
• 58149-70-5 1-(4-Bromo-α-naphthyl)ethyl alcohol 
• 83-53-4 1,4-dibromonaphthalene 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1853997-27-9 2-(1-bromonaphthalen-4-yl)-1,10-phenanthroline 
• 87700-65-0 4-bromo-1-naphthoic acid chloride 
• 1366067-63-1 JWH-394 
• 1366067-59-5 (4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone 
• 1312610-76-6 C₄₄H₄₂N₂O₁₀S₂ 
• 1312611-65-6 C₄₀H₄₆N₂O₁₀ 
• 1312610-75-5 C₂₀H₁₄Br₂O₂ 
• 1312609-63-4 C₂₀H₁₆O₂ 
• 1125724-14-2 1-(4-bromo-1-naphthalenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxy-1-butanone 
• 374926-06-4 2-(4-bromonaphthalene-1-carbonyl)acetonitrile 
• 56052-26-7 (4-bromonaphthalen-1-yl)methanol 
• 79996-99-9 1-bromo-4-bromomethyl-naphthalene 
• 41014-20-4 4-bromomethyl-1-naphthonitrile 

Relevant articles and documents

Dearomative Allylation of Naphthyl Cyanohydrins by Palladium Catalysis: Catalyst-Enhanced Site Selectivity

A dearomative allylation of naphthyl cyanohydrins with allyl borates and allyl stannanes under palladium catalysis was developed. At the initial stage of this study, the dearomative reaction (C4 substitution of the aromatics) was competing with benzyl substitution. To circumvent this issue, the use of palladium and meta-disubstituted triarylphosphine as the catalyst in a 1:1 ratio was found to enhance the site selectivity, furnishing the desired dearomatized products. Further derivatizations of products were also successful.

Concise Synthesis of Polysubstituted Carbohelicenes by a C?H Activation/Radical Reaction/C?H Activation Sequence

Disclosed herein is the merging of C?H activation and radical chemistry, enabling rapid access to a structurally diverse family of fused carbohelicenes through the fusion of α-acetylnaphthalenes with alkynes under oxidative conditions. This cascade process exhibits exquisite chemoselectivity and regioselectivity. The reaction pathway was analyzed by intermediate separations, control experiments, radical trapping, EPR, MALDI-TOF-MS, and ESI-HRMS experiments, and shown to involve a C2?H activation/radical reaction/C8?H activation relay.

Metal-free oxidation of secondary benzylic alcohols using aqueous TBHP

We report a simple, yet efficient metal-free oxidation of secondary benzylic alcohols in the presence of t-butyl hydroperoxide (70% TBHP) with high yields of up to 98%. This type of reaction can be carried out using a wide variety of substrates, requires no other organic solvent, and proves to be tolerant toward a variety of different functional groups.