1366133-39-2Relevant academic research and scientific papers
SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands
Lunn, Graham,Roberts, Lee R.,Content, Stephane,Critcher, Douglas J.,Douglas, Sara,Fenwick, Ashley E.,Gethin, David M.,Goodwin, Graham,Greenway, David,Greenwood, Sean,Hall, Kim,Thomas, Martin,Thompson, Stephen,Williams, David,Wood, Gavin,Wylie, Andrew
, p. 2200 - 2203 (2012/05/04)
3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to
